Estrogen and neurodegenerative diseases information
Estradiol, the major estrogen sex hormone in humans
Neurodegenerative diseases can disrupt the normal human homeostasis and result in abnormal estrogen levels.[1] For example, neurodegenerative diseases can cause different physiological effects in males and females. In particular, estrogen studies have revealed complex interactions with neurodegenerative diseases. Estrogen was initially proposed to be a possible treatment for certain types of neurodegenerative diseases but a plethora of harmful side effects such as increased susceptibility to breast cancer and coronary heart disease overshadowed any beneficial outcomes. On the other hand, Estrogen Replacement Therapy has shown some positive effects with postmenopausal women. Estrogen and estrogen-like molecules form a large family of potentially beneficial alternatives that can have dramatic effects on human homeostasis and disease. Subsequently, large-scale efforts were initiated to screen for useful estrogen family molecules. Furthermore, scientists discovered new ways to synthesize estrogen-like compounds that can avoid many side effects.[citation needed]
^Fratiglioni, L; Grut M; Forsell Y; et al. (December 1991). "Prevalence of Alzheimer's disease and other dementias in an elderly urban population". Neurology. 41 (12): 1886–92. doi:10.1212/wnl.41.12.1886. PMID 1745343. S2CID 43648760.
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Neurodegenerativediseases can disrupt the normal human homeostasis and result in abnormal estrogen levels. For example, neurodegenerativediseases can...
Estrogen (British English: oestrogen; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female...
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potential to treat Alzheimer's and Parkinson's diseaseand other patients with neurodegenerativediseases. 17α-Estradiol (as the sodium salt of its sulfated...
Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear...
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nervous system disorders including neurodegenerativediseases, stroke, traumatic brain injury, spinal cord injury, and acute management of neurotoxin consumption...
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Depakote, and Divalproex. As of 2008, HDIs were being studied as a mitigator for neurodegenerativediseases such as Alzheimer's diseaseand Huntington's...
and age-related neurodegenerativediseases. Similarly to pregnenolone, its synthetic derivative 3β-methoxypregnenolone (MAP-4343), and progesterone, DHEA...
neurotoxic and promotes oxidative stress on neurons. Linsidomine is a peroxynitrite-generating compound involved in the pathogenesis of neurodegenerative diseases...
degradation, which can potentially inhibit the progression of neurodegenerativediseases. For example, Hsp70 overexpression in human neuroglioma cells...
excitotoxicity and prevalence in the central nervous system has been linked or speculated to be linked to many neurodegenerativediseases, and several other...
therapeutic intervention in protein aggregation and improving cellular proteostasis in neurodegenerativediseases. Under the influence of NDFIP1, it undergoes...
involved in many diseases including neurodegenerativediseases, cancers, inflammatory diseases, and aging. The CLU gene contains nine exons and a variety of...
the increased neurodegenerative risk. Microglia are the main immune cells of the central nervous system (CNS) and protect the brain Estrogen is a significant...
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fatty tissues and can, thus, accumulate to harmful levels in these tissues. For example, some OCPs are structurally similar to estrogenand can mimic the...
anddiseases; malfunctions of the immune system in immunological disorders (such as autoimmune diseases, hypersensitivities, immune deficiency, and transplant...
September 2020. Coyle JT (2017). "Schizophrenia: Basic and Clinical". NeurodegenerativeDiseases. Advances in Neurobiology. Vol. 15. pp. 255–280. doi:10...
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