Estratetraenol, also known as estra-1,3,5(10),16-tetraen-3-ol, is an endogenous steroid found in women[1] that has been described as having pheromone-like activities in primates,[2] including humans.[3][4][5][6] Estratetraenol is synthesized from androstadienone by aromatase likely in the ovaries,[7] and is related to the estrogen sex hormones, yet has no known estrogenic effects. It was first identified from the urine of pregnant women.[8]
Estratetraenyl acetate, or estra-1,3,5(10),16-tetraen-3-yl acetate, is a more potent synthetic derivative of estratetraenol.[9]
Estratetraenol is an estrane (C18) steroid and an analogue of estradiol where the C17β hydroxyl group has been removed and a double bond has been formed between the C16 and C17 positions.
^Thysen B, Elliott WH, Katzman PA (January 1968). "Identification of estra-1,3,5(10),16-tetraen-3-ol (estratetraenol) from the urine of pregnant women (1)". Steroids. 11 (1): 73–87. doi:10.1016/S0039-128X(68)80052-2. PMID 4295975.
^Laska M, Wieser A, Salazar LT (May 2006). "Sex-specific differences in olfactory sensitivity for putative human pheromones in nonhuman primates". Journal of Comparative Psychology. 120 (2): 106–112. doi:10.1037/0735-7036.120.2.106. PMID 16719588.
^Jacob S, Hayreh DJ, McClintock MK (2001). "Context-dependent effects of steroid chemosignals on human physiology and mood". Physiology & Behavior. 74 (1–2): 15–27. doi:10.1016/S0031-9384(01)00537-6. PMID 11564447. S2CID 19312085.
^Savic I, Berglund H, Gulyas B, Roland P (August 2001). "Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans". Neuron. 31 (4): 661–668. doi:10.1016/S0896-6273(01)00390-7. PMID 11545724. S2CID 2547202.
^Berglund H, Lindström P, Savic I (May 2006). "Brain response to putative pheromones in lesbian women". Proceedings of the National Academy of Sciences of the United States of America. 103 (21): 8269–8274. Bibcode:2006PNAS..103.8269B. doi:10.1073/pnas.0600331103. PMC 1570103. PMID 16705035.
^Berglund H, Lindström P, Dhejne-Helmy C, Savic I (August 2008). "Male-to-female transsexuals show sex-atypical hypothalamus activation when smelling odorous steroids". Cerebral Cortex. 18 (8): 1900–1908. doi:10.1093/cercor/bhm216. PMID 18056697.
^Weusten JJ (1989). Biochemical pathways in human testicular steroidogenesis(PDF) (Ph.D. thesis). Pressa Trajectina.
^Thysen B, Elliott WH, Katzman PA (January 1968). "Identification of estra-1,3,5(10),16-tetraen-3-ol (estratetraenol) from the urine of pregnant women (1)". Steroids. 11 (1): 73–87. doi:10.1016/s0039-128x(68)80052-2. PMID 4295975.
^Lundström JN (2005). Human pheromones : psychological and neurological modulation of a putative human pheromone (Ph.D. thesis). Uppsala: Acta Universitatis Upsaliensis. p. 17. ISBN 91-554-6297-9.
Estratetraenol, also known as estra-1,3,5(10),16-tetraen-3-ol, is an endogenous steroid found in women that has been described as having pheromone-like...
androstadienol, androstadienone, androstenol, and androstenone and the estrane estratetraenol. Certain other endogenous steroids, such as pregnenolone, progesterone...
3β-hydroxysteroid dehydrogenase. 3β-Androstanediol Androstenol Androstenone Estratetraenol Yalkowsky SH, He Y, Jain P (19 April 2016). Handbook of Aqueous Solubility...
including androstadienone, androstenone, androstenol, androsterone, and estratetraenol. Fasedienol (PH94B; Aloradine; 4,16-androstadien-3β-ol) is an investigational...
37 g/mol, exact mass: 254.1671 u) may refer to: Enzacamene (4-MBC) Estratetraenol, or estra-1,3,5(10),16-tetraen-3-ol This set index page lists chemical...
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