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Androstadienone information


Androstadienone
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • (8S,9S,10R,13R,14S)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthren-3-one
CAS Number
  • 4075-07-4 checkY
PubChem CID
  • 92979
ChemSpider
  • 83932 checkY
UNII
  • ZUZ4FHD36E
CompTox Dashboard (EPA)
  • DTXSID00863314 Edit this at Wikidata
Chemical and physical data
FormulaC19H26O
Molar mass270.416 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC=C2)CCC4=CC(=O)CC[C@]34C
InChI
  • InChI=1S/C19H26O/c1-18-9-3-4-16(18)15-6-5-13-12-14(20)7-11-19(13,2)17(15)8-10-18/h3,9,12,15-17H,4-8,10-11H2,1-2H3/t15-,16-,17-,18-,19-/m0/s1 checkY
  • Key:HNDHDMOSWUAEAW-VMXHOPILSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Androstadienone, or androsta-4,16-dien-3-one, is a 16-androstene class endogenous steroid that has been described as having potent pheromone-like activities in humans.[1] The compound is synthesized from androstadienol by 3β-hydroxysteroid dehydrogenase, and can be converted into androstenone (a more potent and odorous pheromone) by 5α-reductase, which can subsequently be converted into 3α-androstenol or 3β-androstenol (also more potent and odorous pheromones) by 3-ketosteroid reductase.[2]

Androstadienone is related to the androgen sex hormones; however, androstadienone does not exhibit any androgenic or anabolic effects. Though it has been reported to significantly affect the mood of heterosexual women and homosexual men, it does not alter behavior overtly,[3][4][5][6] although it may have more subtle effects on attention.[7]

Androstadienone is commonly sold in male fragrances; it is purported to increase sexual attraction. Androstadienone, in picogram quantities, has been shown to have "significant reduction of nervousness, tension and other negative feeling states" in female subjects.[8]

  1. ^ Wyart C, Webster WW, Chen JH, Wilson SR, McClary A, Khan RM, Sobel N (February 2007). "Smelling a single component of male sweat alters levels of cortisol in women". The Journal of Neuroscience. 27 (6): 1261–1265. doi:10.1523/JNEUROSCI.4430-06.2007. PMC 6673596. PMID 17287500.
  2. ^ Weusten AM (1989). Biochemical pathways in human testicular steroidogenesis (PDF) (Ph.D. thesis). Pressa Trajectina, Universiteit Utrecht.
  3. ^ Lundström JN, Olsson MJ (December 2005). "Subthreshold amounts of social odorant affect mood, but not behavior, in heterosexual women when tested by a male, but not a female, experimenter". Biological Psychology. 70 (3): 197–204. doi:10.1016/j.biopsycho.2005.01.008. PMID 16242537. S2CID 12401158.
  4. ^ Gabrielsen P (2 June 2013). "Mens' [sic] Sweat Pheromone, Androstadienone, Influences Cooperation In Other Men". HuffPost. Retrieved March 14, 2016.
  5. ^ "Human Pheromone Molecules". House of Pheromones. Archived from the original on March 27, 2016. Retrieved March 14, 2016.
  6. ^ Yuhas D (1 May 2014). "Human Sexual Responses Boosted by Bodily Scents". Scientific American. Retrieved March 14, 2016.
  7. ^ Hummer TA, McClintock MK (April 2009). "Putative human pheromone androstadienone attunes the mind specifically to emotional information". Hormones and Behavior. 55 (4): 548–559. doi:10.1016/j.yhbeh.2009.01.002. PMID 19470369. S2CID 17022112.
  8. ^ Grosser BI, Monti-Bloch L, Jennings-White C, Berliner DL (April 2000). "Behavioral and electrophysiological effects of androstadienone, a human pheromone". Psychoneuroendocrinology. 25 (3): 289–299. doi:10.1016/s0306-4530(99)00056-6. PMID 10737699. S2CID 41960611.

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Androstadienone

Last Update:

Androstadienone, or androsta-4,16-dien-3-one, is a 16-androstene class endogenous steroid that has been described as having potent pheromone-like activities...

Word Count : 442

Androstenol

Last Update:

3β-hydroxysteroid dehydrogenase (androstadienol to androstadienone), 5α-reductase (androstadienone to androstenone), and 3α-hydroxysteroid dehydrogenase...

Word Count : 693

Pheromone

Last Update:

ovulation. Androstadienone seems to affect the limbic system and causes a positive reaction in women, improving mood. Responses to androstadienone depend...

Word Count : 6190

Armpit fetishism

Last Update:

temporary energy boost. Certain pheromones found in armpit sweat, namely androstadienone is shown to improve mood when smelled or licked according to a 2013...

Word Count : 598

Androstadienol

Last Update:

that is found in the sweat of both men and women. Androstadienol and androstadienone are odorless compounds secreted by the apocrine glands, and via conversion...

Word Count : 430

Fear

Last Update:

was interpreted as androstadienone-related activation of the fear system. A potential mechanism of action is, that androstadienone alters the "emotional...

Word Count : 12325

List of androstanes

Last Update:

δ4-Androstadienol (δ4,16-androstadien-3β-ol) – a synthetic pherine Androstadienone δ4-Androstadienone (δ4,16-androstadien-3-one) – an endogenous pheromone Many...

Word Count : 377

Hyperosmia

Last Update:

human odorant receptor OR7D4 are more sensitive to androstenone and androstadienone and thus find them unpleasant (individuals with the semi-functional...

Word Count : 651

Cortisol

Last Update:

Etiocholanolone Pheromones: 3α-Androstenol 3β-Androstenol Androstadienol Androstadienone Androstenone Androsterone Estratetraenol Others Vitamin D: 7-Dehydrocholesterol...

Word Count : 8516

Progesterone

Last Update:

Etiocholanolone Pheromones: 3α-Androstenol 3β-Androstenol Androstadienol Androstadienone Androstenone Androsterone Estratetraenol Others Vitamin D: 7-Dehydrocholesterol...

Word Count : 11590

Estrogen

Last Update:

Etiocholanolone Pheromones: 3α-Androstenol 3β-Androstenol Androstadienol Androstadienone Androstenone Androsterone Estratetraenol Others Vitamin D: 7-Dehydrocholesterol...

Word Count : 7575

Corticosteroid

Last Update:

Etiocholanolone Pheromones: 3α-Androstenol 3β-Androstenol Androstadienol Androstadienone Androstenone Androsterone Estratetraenol Others Vitamin D: 7-Dehydrocholesterol...

Word Count : 4133

Fasedienol

Last Update:

effects. It produces anxiolytic-like effects in animals. Androstadienol, androstadienone, and androstenone, all of which are also pheromones, have been found...

Word Count : 625

Steroid

Last Update:

Androstenedione Androstenetrione Androstanolone Androstenolone Androstadienol Androstadienone; Etiocholane C20 19-Norpregnane C21 Pregnane: Dehydrogenated: Pregnene...

Word Count : 8393

Testosterone

Last Update:

Etiocholanolone Pheromones: 3α-Androstenol 3β-Androstenol Androstadienol Androstadienone Androstenone Androsterone Estratetraenol Others Vitamin D: 7-Dehydrocholesterol...

Word Count : 15741

Glucocorticoid

Last Update:

Etiocholanolone Pheromones: 3α-Androstenol 3β-Androstenol Androstadienol Androstadienone Androstenone Androsterone Estratetraenol Others Vitamin D: 7-Dehydrocholesterol...

Word Count : 5521

Aldosterone

Last Update:

Etiocholanolone Pheromones: 3α-Androstenol 3β-Androstenol Androstadienol Androstadienone Androstenone Androsterone Estratetraenol Others Vitamin D: 7-Dehydrocholesterol...

Word Count : 3377

Androgen

Last Update:

Etiocholanolone Pheromones: 3α-Androstenol 3β-Androstenol Androstadienol Androstadienone Androstenone Androsterone Estratetraenol Others Vitamin D: 7-Dehydrocholesterol...

Word Count : 3165

Secosteroid

Last Update:

Androstenedione Androstenetrione Androstanolone Androstenolone Androstadienol Androstadienone; Etiocholane C20 19-Norpregnane C21 Pregnane: Dehydrogenated: Pregnene...

Word Count : 386

Estradiol

Last Update:

Etiocholanolone Pheromones: 3α-Androstenol 3β-Androstenol Androstadienol Androstadienone Androstenone Androsterone Estratetraenol Others Vitamin D: 7-Dehydrocholesterol...

Word Count : 7059

Pherine

Last Update:

and pharmacologically different from natural pheromones including androstadienone, androstenone, androstenol, androsterone, and estratetraenol. Fasedienol...

Word Count : 753

Pregnenolone

Last Update:

Etiocholanolone Pheromones: 3α-Androstenol 3β-Androstenol Androstadienol Androstadienone Androstenone Androsterone Estratetraenol Others Vitamin D: 7-Dehydrocholesterol...

Word Count : 2059

Estratetraenol

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in primates, including humans. Estratetraenol is synthesized from androstadienone by aromatase likely in the ovaries, and is related to the estrogen...

Word Count : 655

Dihydrotestosterone

Last Update:

Etiocholanolone Pheromones: 3α-Androstenol 3β-Androstenol Androstadienol Androstadienone Androstenone Androsterone Estratetraenol Others Vitamin D: 7-Dehydrocholesterol...

Word Count : 6821

Steroid hormone

Last Update:

Etiocholanolone Pheromones: 3α-Androstenol 3β-Androstenol Androstadienol Androstadienone Androstenone Androsterone Estratetraenol Others Vitamin D: 7-Dehydrocholesterol...

Word Count : 1674

Olfactic communication

Last Update:

with a masculine scent. This scent contained higher concentrations of androstadienone. Scent donors were rated on cooperativeness before the sample was taken...

Word Count : 3902

Mineralocorticoid

Last Update:

Etiocholanolone Pheromones: 3α-Androstenol 3β-Androstenol Androstadienol Androstadienone Androstenone Androsterone Estratetraenol Others Vitamin D: 7-Dehydrocholesterol...

Word Count : 723

Androstenone

Last Update:

timing of artificial insemination. Androstenone is synthesized from androstadienone by 5α-reductase, and can be converted into 3α-androstenol or 3β-androstenol...

Word Count : 1148

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