Esmolol, sold under the brand name Brevibloc, is a cardio selective beta1 receptor blocker with rapid onset,[3] a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages.
It is a class II antiarrhythmic.[4] Esmolol decreases the force and rate of heart contractions by blocking beta-adrenergic receptors of the sympathetic nervous system, which are found in the heart and other organs of the body. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine.[5]
It was patented in 1980 and approved for medical use in 1987.[6]
^"Brevibloc esmolol hydrochloride 2.5 g powder for injection for infusion vial (310943)". Therapeutic Goods Administration (TGA). 26 May 2022. Retrieved 29 April 2023.
^"Esmolol Juno (Juno Pharmaceuticals Pty Ltd)". Therapeutic Goods Administration (TGA). 13 January 2023. Archived from the original on 18 March 2023. Retrieved 29 April 2023.
^Deng CY, Lin SG, Zhang WC, Kuang SJ, Qian WM, Wu SL, et al. (December 2006). "Esmolol inhibits Na+ current in rat ventricular myocytes". Methods and Findings in Experimental and Clinical Pharmacology. 28 (10): 697–702. doi:10.1358/mf.2006.28.10.1037498. PMID 17235414. Archived from the original on 2019-12-10. Retrieved 2008-07-27.
^Jaillon P, Drici M (December 1989). "Recent antiarrhythmic drugs". The American Journal of Cardiology. 64 (20): 65J–69J. doi:10.1016/0002-9149(89)91203-4. PMID 2688391.
^Tripathi KD. "Antiadrenergic Drugs and Drugs for Glaucoma". Essentials of Medical Pharmacology (7th ed.). p. 149.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 462. ISBN 978-3-527-60749-5.
Esmolol, sold under the brand name Brevibloc, is a cardio selective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant...
lipophilicity or hydrophilic beta blockers include atenolol, carteolol, esmolol, labetalol, nadolol, and sotalol. It is thought that highly lipophilic...
decrease conduction through the AV node. Class II agents include atenolol, esmolol, propranolol, and metoprolol. Class III agents predominantly block the...
Friedman B, Smith M (June 1990). "Acute theophylline toxicity and the use of esmolol to reverse cardiovascular instability". Annals of Emergency Medicine. 19...
given intravenously and have doses that are easier to adjust (such as esmolol, propranolol, or labetalol) is preferred. Vasodilators such as sodium nitroprusside...
desired. Landiolol was developed by modifying the chemical structure of esmolol to produce a compound with a higher rate of cardioselectivity and a greater...
Suttner S (September 2007). "Combined use of ultra-short acting beta-blocker esmolol and intravenous phosphodiesterase 3 inhibitor enoximone". Expert Opin Pharmacother...
putative cases of "unopposed alpha-stimulation" due to propranolol (n=3), esmolol (n=3), and metoprolol (n=1). Some detractors of beta-blockers for cocaine-induced...
treated with short-acting antihypertensive drugs such as nitroprusside or esmolol; longer acting drugs such as propranolol should be avoided as they may...
rhythm. Acute attacks of supraventricular tachycardia are treated with Esmolol (i.v.). Notable cases of SVT: Bobby Julich, American professional road...
and anxiety disorders. Common examples include atenolol, bisoprolol, esmolol, metoprolol, and nebivolol. Beta 2 blockers primarily contract the smooth...
propafenone, moricizine) Class II — Beta blockers (carvedilol, propranolol, esmolol, timolol, metoprolol, atenolol, bisoprolol) Class III — Potassium channel...
rupture while the heart rate should be kept under 100 beats per minute. Esmolol is first choice to maintain blood pressure and heart rate due to its short...
agonist used as a cardiac stimulant and in the treatment of anaphylaxis Esmolol – a beta blocker Fenoldopam – a D1 receptor agonist used as an antihypertensive...
designed soft drugs that have either already reached the market, such as esmolol (Breviblock) landiolol (Onoact) remifentanil (Ultiva) loteprednol etabonate...
A, Alagöl A, Uzer SS, Ege T, Turan N, Duran E, Pamukcu Z. "The Use of Esmolol and Magnesium to prevent Haemodynamic Responses to Extubation After Coronary...
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