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Cocaine addiction is the compulsive use of cocaine despite adverse consequences. It arises through epigenetic modification (e.g., through HDAC, sirtuin, and G9a) and transcriptional regulation (primarily through ΔFosB's AP-1 complex) of genes in the nucleus accumbens.
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Cocaineaddiction is the compulsive use ofcocaine despite adverse consequences. It arises through epigenetic modification (e.g., through HDAC, sirtuin...
Examples of drug (or more generally, substance) addictions include alcoholism, cannabis addiction, amphetamine addiction, cocaineaddiction, nicotine...
accumbens. (See, for example, Epigeneticsofcocaineaddiction.) DNA damage appears to be the primary underlying cause of cancer. If accurate DNA repair...
methylation at CpG sites, and (3) epigenetic downregulation or upregulation of microRNAs. (See Epigeneticsofcocaineaddiction for some details.) Chronic nicotine...
single dose ofcocaine induces tolerance to the drug's effects. Repeated use is likely to result in addiction. Addicts who abstain from cocaine may experience...
of developing an addiction to cocaine. As of 2018,[update] neither the heritability of these epigenetic marks in humans nor the behavioral effects of...
sufficient for many of the neural adaptations seen in drug addiction; it has been implicated in addictions to alcohol, cannabinoids, cocaine, nicotine, phenylcyclidine...
Behavioral epigenetics is the field of study examining the role ofepigenetics in shaping animal and human behavior. It seeks to explain how nurture shapes...
like addictive substances cause severe psychological dependence such as cocaine, morphine, and nicotine. Caffeine dependence forms due to caffeine antagonizing...
cannabis addiction or marijuana addiction, is a psychiatric disorder defined in the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders...
4: Epigenetic basis of drug regulation of gene expression Hitchcock LN, Lattal KM (2014). "Histone-mediated epigenetics in addiction". Epigenetics and...
sensitization) seen in drug addiction. ΔFosB overexpression has been implicated in addictions to alcohol (ethanol), cannabinoids, cocaine, methylphenidate, nicotine...
treatment for psychostimulant addiction is generally unsatisfactory. As previously discussed, cessation ofcocaine use and the use of other psychostimulants...
of substances like legal or illegal drugs, alcohol, or medications. Symptoms can be moderate to severe, with addiction being the most severe form of SUD"...
treatment for psychostimulant addiction is generally unsatisfactory. As previously discussed, cessation ofcocaine use and the use of other psychostimulants...
abuse (cocaine, amphetamine) and can occur with many drugs that are not abused (propranolol, clonidine). The official diagnosis of drug addiction by the...
treatment for psychostimulant addiction is generally unsatisfactory. As previously discussed, cessation ofcocaine use and the use of other psychostimulants...
in nicotine, caffeine, alcohol, cocaine, opioid, and cannabis use: A focused review". The American Journal on Addictions. 24 (7): 590–8. doi:10.1111/ajad...
present a smaller addiction potential than cocaine or methamphetamine. Ries R, Miller SC, Fiellin DA (2009). Principles ofaddiction medicine (4th ed.)...
agitation, and a low mood. Addiction and dependence are important components of opioid use disorder. Risk factors include a history of opioid misuse, current...
PMID 21989194. Hitchcock LN, Lattal KM (2014). "Histone-mediated epigenetics in addiction". Epigenetics and Neuroplasticity—Evidence and Debate. Progress in Molecular...
performance. Some of the most common stimulants are caffeine, nicotine, amphetamines, cocaine, and modafinil. Stimulants work by affecting the levels of certain...
is medical evidence to support the existence of actual addiction to chocolate. Psychoactive constituents of chocolate that trigger a ‘feel-good’ reaction...
explicit role in longer-term aspects ofaddiction. Pontieri FE, Tanda G, Di Chiara G (December 1995). "Intravenous cocaine, morphine, and amphetamine preferentially...
probability of later use of cannabis and cocaine, as well as other drugs. In rats, alcohol increased the probability of later addiction to cocaine and again...
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