FBXO5 information

FBXO5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M6N, 4UI9
Identifiers
Aliases	FBXO5, EMI1, FBX5, Fbxo31, F-box protein 5
External IDs	OMIM: 606013; MGI: 1914391; HomoloGene: 8135; GeneCards: FBXO5; OMA:FBXO5 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	152,983,579 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	5,755,600 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; secondary oocyte; ; bone marrow; ; bone marrow cells; ; trabecular bone; ; lymph node; ; stromal cell of endometrium; ; appendix; ; rectum; ; monocyte;
	Top expressed in
	hand; ; superior cervical ganglion; ; maxillary prominence; ; primitive streak; ; abdominal wall; ; medial ganglionic eminence; ; thymus; ; secondary oocyte; ; morula; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; protein kinase binding; ubiquitin ligase inhibitor activity; anaphase-promoting complex binding;
Cellular component	cytoplasm; cytosol; spindle; nucleoplasm; cytoskeleton; nucleus; meiotic spindle;
Biological process	vesicle organization; regulation of meiotic nuclear division; microtubule polymerization; negative regulation of meiotic nuclear division; regulation of transcription involved in G1/S transition of mitotic cell cycle; cell division; spindle assembly; oocyte maturation; regulation of mitotic cell cycle; cell cycle; spindle assembly involved in female meiosis I; regulation of mitotic nuclear division; negative regulation of ubiquitin protein ligase activity; anaphase-promoting complex-dependent catabolic process; negative regulation of mitotic metaphase/anaphase transition; regulation of DNA replication; positive regulation of cell population proliferation; positive regulation of G2/M transition of mitotic cell cycle; negative regulation of DNA endoreduplication; positive regulation of osteoblast differentiation; negative regulation of ubiquitin-protein transferase activity; positive regulation of biomineral tissue development; positive regulation of mesenchymal stem cell migration; negative regulation of cellular senescence; negative regulation of response to DNA damage stimulus; protein ubiquitination; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	26271
	67141
	ENSG00000112029
	ENSMUSG00000019773
	Q9UKT4
	Q7TSG3
	NM_001142522; NM_012177
	NM_025995
	NP_001135994; NP_036309
	NP_080271
	Wikidata
View/Edit Human	View/Edit Mouse

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112029 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019773 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (October 1999). "A family of mammalian F-box proteins". Current Biology. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
^ "Entrez Gene: FBXO5 F-box protein 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112029 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019773 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10531035-5] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.

[pmid10531037-6] Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (October 1999). "A family of mammalian F-box proteins". Current Biology. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.

[entrez-7] "Entrez Gene: FBXO5 F-box protein 5".

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