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Drostanolone propionate information


Drostanolone propionate
Clinical data
Trade namesDrolban, Masteril, Masteron, others
Other namesDromostanolone propionate; NSC-12198; Drostanolone 17β-propionate; 2α-Methyl-4,5α-dihydrotestosterone 17β-propionate; 2α-Methyl-DHT propionate; 2α-Methyl-5α-androstan-17β-ol-3-one 17β-propionate
Pregnancy
category
  • X
Routes of
administration
Intramuscular injection[1]
Drug classAndrogen; Anabolic steroid; Androgen ester
ATC code
  • A14
Legal status
Legal status
  • CA: Schedule IV
  • US: Schedule III
Pharmacokinetic data
BioavailabilityOral: 0–2%
Intramuscular: 100%
Protein bindingHigh
MetabolismHepatic
Elimination half-lifeIntramuscular: 2 days[1]
ExcretionUrine
Identifiers
IUPAC name
  • (2R,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
CAS Number
  • 58-19-5 checkY
PubChem CID
  • 224004
IUPHAR/BPS
  • 6947
DrugBank
  • DB00858 checkY
ChemSpider
  • 194604 checkY
UNII
  • 7DR7H00HDT
ChEBI
  • CHEBI:31523 checkY
CompTox Dashboard (EPA)
  • DTXSID1022971 Edit this at Wikidata
ECHA InfoCard100.007.550 Edit this at Wikidata
Chemical and physical data
FormulaC23H36O3
Molar mass360.538 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CCC(=O)O[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(C[C@H](C(=O)C4)C)C)C
InChI
  • InChI=1S/C23H36O3/c1-5-21(25)26-20-9-8-17-16-7-6-15-12-19(24)14(2)13-23(15,4)18(16)10-11-22(17,20)3/h14-18,20H,5-13H2,1-4H3/t14-,15+,16+,17+,18+,20+,22+,23+/m1/s1 checkY
  • Key:NOTIQUSPUUHHEH-UXOVVSIBSA-N checkY
  (verify)

Drostanolone propionate, or dromostanolone propionate, sold under the brand names Drolban, Masteril, and Masteron among others, is an androgen and anabolic steroid (AAS) medication which was used to treat breast cancer in women but is now no longer marketed.[1][2] It is given by injection into muscle.[1]

Side effects of drostanolone propionate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire.[1] It has no risk of liver damage.[1] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).[1][3] It has moderate anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women.[1] The drug has no estrogenic effects.[1] Drostanolone propionate is an androgen ester and a long-lasting prodrug of drostanolone in the body.[1]

Drostanolone propionate was first described in 1959 and was introduced for medical use in 1961.[1][4][5] In addition to its medical use, drostanolone propionate is used to improve physique and performance.[1] The drug is a controlled substance in many countries and so non-medical use is generally illicit.[1][6]

  1. ^ a b c d e f g h i j k l m Llewellyn W (2011). Anabolics. Molecular Nutrition Llc. pp. 517–. ISBN 978-0-9828280-1-4.
  2. ^ "Anabolic Agents". Drugs.com.
  3. ^ Kicman AT (June 2008). "Pharmacology of anabolic steroids". British Journal of Pharmacology. 154 (3): 502–521. doi:10.1038/bjp.2008.165. PMC 2439524. PMID 18500378.
  4. ^ Cite error: The named reference RingoldBatres1959 was invoked but never defined (see the help page).
  5. ^ Cite error: The named reference Publishing2013 was invoked but never defined (see the help page).
  6. ^ Cite error: The named reference FFFLM2006 was invoked but never defined (see the help page).

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