Global InformationDiaminopimelate decarboxylase information
 A cartoon of Methanococcus jannaschii diaminopimelate decarboxylase | |||||||||
| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| EC no. | 4.1.1.20 | ||||||||
| CAS no. | 9024-75-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme diaminopimelate decarboxylase (EC 4.1.1.20) catalyzes the cleavage of carbon-carbon bonds in meso 2,6 diaminoheptanedioate to produce CO2 and L-lysine, the essential amino acid. It employs the cofactor pyridoxal phosphate, also known as PLP, which participates in numerous enzymatic transamination, decarboxylation and deamination reactions.[1]
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming).DAP-decarboxylase catalyzes the final step in the meso-diaminopimelate/lysine biosynthetic pathway.[2] Lysine is used for protein synthesis and used in the peptidoglycan layer of Gram-positive bacteria cell walls.[2] This enzyme is not found in humans, but the ortholog is ornithine decarboxylase.[3]
- ^ "Pyridoxal phosphate". Pubchem. Retrieved 2018-03-09.
- ^ a b Gillner DM, Becker DP, Holz RC (February 2013). "Lysine biosynthesis in bacteria: a metallodesuccinylase as a potential antimicrobial target". Journal of Biological Inorganic Chemistry. 18 (2): 155–63. doi:10.1007/s00775-012-0965-1. PMC 3862034. PMID 23223968.
- ^ Peverelli MG, Soares da Costa TP, Kirby N, Perugini MA (April 2016). "Dimerization of Bacterial Diaminopimelate Decarboxylase Is Essential for Catalysis". The Journal of Biological Chemistry. 291 (18): 9785–95. doi:10.1074/jbc.M115.696591. PMC 4850314. PMID 26921318.