Chemical reaction in which a carbon-halogen bond is cleaved
Scheme for dehalogenation reaction (R = alkyl or aryl group, X = I, Cl, Br, F)
In organic chemistry, dehalogenation is a set of chemical reactions that involve the cleavage of carbon-halogen bonds; as such, it is the inverse reaction of halogenation. Dehalogenations come in many varieties, including defluorination (removal of fluorine), dechlorination (removal of chlorine), debromination (removal of bromine), and deiodination (removal of iodine). Incentives to investigate dehalogenations include both constructive and destructive goals. Complicated organic compounds such as pharmaceutical drugs are occasionally generated by dehalogenation. Many organohalides are hazardous, so their dehalogenation is one route for their detoxification.[1]
^Smidt, Hauke; De Vos, Willem M. (2004). "Anaerobic Microbial Dehalogenation". Annual Review of Microbiology. 58: 43–73. doi:10.1146/annurev.micro.58.030603.123600. PMID 15487929.
In organic chemistry, dehalogenation is a set of chemical reactions that involve the cleavage of carbon-halogen bonds; as such, it is the inverse reaction...
reaction additives. Like tin-mediated radical dehalogenation reactions, photocatalytic reductive dehalogenation can be used to initiate cascade cyclizations...
Nickel boride is the common name of materials composed chiefly of the elements nickel and boron that are widely used as catalysts in organic chemistry...
cyclohexylcobalamin. This reaction is under review for use as a catalyst for chemical dehalogenation, organic reagent and photosensitized catalyst systems. Cyanocobalamin...
5-dibromo-4-hydroxybenzoic acid) have been shown to undergo metabolic reductive dehalogenation by the microorganism Desulfitobacterium chlororespirans. In the Great...
Schnöckel and coworkers later showed an alternative synthesis involving the dehalogenation of hexachlorophosphazene with molten silver, with concomitant loss of...
trimethylenemethane complexes are synthesized in the following four ways: (A) the dehalogenation of α, α'-dihalosubstituted precursors, (B) the thermal extrusion of...
irradiation with UV-light. 1,4-Dihalobutanes convert to cyclobutanes upon dehalogenation with reducing metals. Cyclobutane was first synthesized in 1907 by James...
Silver acetate is a coordination compound with the empirical formula CH3CO2Ag (or AgC2H3O2). A photosensitive, white, crystalline solid, it is a useful...
alcohol, respectively. The alcoholysis of acyl halides (the alkoxy-dehalogenation) is believed to proceed via an SN2 mechanism (Scheme 10). However,...
Dehalogenation in aerobic organisms is usually done through oxidation and hydrolysis; however, iodotyrosine deiodinase uses reductive dehalogenation....
is a mammalian enzyme with the unusual function of aerobic reductive dehalogenation of iodine- or bromine-substituted organic substrates. Bromoxynil and...
carboxylic anhydride. Ketones can be prepared from haloketones in reductive dehalogenation of halo ketones. In ketonic decarboxylation symmetrical ketones are...
elimination reaction with Burgess reagent oxidation with p-chloranil dehalogenation with polymethylhydrosiloxane, palladium(II) acetate, potassium phosphate...
Amine alkylation (amino-dehalogenation) is a type of organic reaction between an alkyl halide and ammonia or an amine. The reaction is called nucleophilic...
A.; Arnold R. G.; Kuhler R. J.; Santo G. A. (June 2005). "Reductive dehalogenation of bromoform in aqueous solution". Environ. Health Perspect. 103 (Suppl...
In organic chemistry, α-halo ketones can be reduced with loss of the halogen atom to form enolates. The α-halo ketones are readily prepared from ketones...
through photolysis. The main biodegradative pathway for PCP is reductive dehalogenation. In this process, the compound PCP is broken down to tetrachlorophenols...
Like other halogenated pesticides, bromoxynil is subject to reductive dehalogenation under anaerobic conditions, and can be debrominated by organisms originally...
obtain energy via the oxidation of hydrogen and subsequent reductive dehalogenation of halogenated organic compounds in a mode of anaerobic respiration...
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