The degranulation process in a Mast cell. 1 = antigen; 2 = IgE; 3 = FcεR1; 4 = preformed mediators (histamine, proteases, chemokines, heparin); 5 = granules; 6 - Mast cell; 7 - newly formed mediators (prostaglandins, leukotrienes, thromboxanes, platelet-activating factor)
Degranulation is a cellular process that releases antimicrobial cytotoxic or other molecules from secretory vesicles called granules found inside some cells. It is used by several different cells involved in the immune system, including granulocytes (neutrophils, basophils, eosinophils, and mast cells). It is also used by certain lymphocytes such as natural killer (NK) cells and cytotoxic T cells, whose main purpose is to destroy invading microorganisms.
Degranulation is a cellular process that releases antimicrobial cytotoxic or other molecules from secretory vesicles called granules found inside some...
cell can either selectively release (piecemeal degranulation) or rapidly release (anaphylactic degranulation) "mediators", or compounds that induce inflammation...
major basic protein. These mediators are released by a process called degranulation following activation of the eosinophil, and are toxic to both parasite...
methods for directly attacking micro-organisms: phagocytosis (ingestion), degranulation (release of soluble anti-microbials), and generation of neutrophil extracellular...
cross-links the bound IgE on sensitized cells, resulting in anaphylactic degranulation, which is the immediate and explosive release of pharmacologically active...
aggravate their condition. Wheals and angioedema appear to be caused by the degranulation of skin mast cells in CSU. These cells secrete proteases, histamine...
histamine increase in victim tissue – because it does not cause mast cell degranulation – and is not immunogenic. Hornets, like many social wasps, can mobilize...
the bound IgE and the aggregation of the underlying FcεRI, leading to degranulation (the release of mediators) and the secretion of several types of type...
to prevent or treat certain allergic disorders. They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine...
response lies mainly in preventing cytosolic Ca2+ increase and preventing degranulation and histamine release in mast cells and human basophils. K252b inhibits...
substance triggering an allergic response upon degranulation. The cells are activated and start degranulation when the IgE antibody, bound to an allergen...
together by 3 disulfide bridges. Anaphylatoxins are able to trigger degranulation (release of substances) of endothelial cells, mast cells or phagocytes...
serine proteases, myeloperoxidase, lactoferrin and antibiotic proteins. Degranulation of these into the phagosome, accompanied by high reactive oxygen species...
contrast among others) cause anaphylaxis by directly triggering mast cell degranulation. The frequency of a reaction to an agent partly depends on the frequency...
calcium mobilization and neutrophil degranulation. FcγRIIIa and FcγRIIIb together are able to activate degranulation, phagocytosis, and oxidative burst...
to death. Type I hypersensitivity is mediated by IgE, which triggers degranulation of mast cells and basophils when cross-linked by antigen. Type II hypersensitivity...
thought to alter adenosine release and inhibit IgE mediated mast cell degranulation, Sulfasalazine is a good option for people with anemia who cannot take...
"Inherent low Erk and p38 activity reduce Fas Ligand expression and degranulation in T helper 17 cells leading to activation induced cell death resistance"...
In the case of allergic rhinitis, the inflammation is caused by the degranulation of mast cells in the nose. When mast cells degranulate, they release...
results in platelet-shape change, inside-out activation of integrins, and degranulation. Circulating fibrinogen binds these receptors on adjacent platelets...
heavy chains) binds to Fc receptor ε on a mast cell, triggering its degranulation: the release of molecules stored in its granules. The antibody isotype...
sensitized cell. Activated mast cells and basophils undergo a process called degranulation, during which they release histamine and other inflammatory chemical...
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