Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Nverify (what is YN ?)
Infobox references
Chemical compound
Thromboxane A2 (TXA2) is a type of thromboxane that is produced by activated platelets during hemostasis and has prothrombotic properties: it stimulates activation of new platelets as well as increases platelet aggregation. This is achieved by activating the thromboxane receptor, which results in platelet-shape change, inside-out activation of integrins, and degranulation.[1] Circulating fibrinogen binds these receptors on adjacent platelets, further strengthening the clot. Thromboxane A2 is also a known vasoconstrictor[2][3][4][5] and is especially important during tissue injury and inflammation. It is also regarded as responsible for Prinzmetal's angina.
Receptors that mediate TXA2 actions are thromboxane A2 receptors. The human TXA2 receptor (TP) is a typical G protein-coupled receptor (GPCR) with seven transmembrane segments. In humans, two TP receptor splice variants – TPα and TPβ – have so far been cloned.
^Offermanns S (2006-12-08). "Activation of Platelet Function Through G Protein–Coupled Receptors". Circulation Research. 99 (12): 1293–1304. doi:10.1161/01.res.0000251742.71301.16. ISSN 0009-7330. PMID 17158345.
^Ding X, Murray PA (November 2005). "Cellular mechanisms of thromboxane A2-mediated contraction in pulmonary veins". American Journal of Physiology. Lung Cellular and Molecular Physiology. 289 (5): L825–833. doi:10.1152/ajplung.00177.2005. ISSN 1040-0605. PMID 15964897. S2CID 3171857.
^Yamamoto K, Ebina S, Nakanishi H, Nakahata N (November 1995). "Thromboxane A2 receptor-mediated signal transduction in rabbit aortic smooth muscle cells". General Pharmacology. 26 (7): 1489–1498. doi:10.1016/0306-3623(95)00025-9. ISSN 0306-3623. PMID 8690235.
^Smyth EM (2010-04-01). "Thromboxane and the thromboxane receptor in cardiovascular disease". Clinical Lipidology. 5 (2): 209–219. doi:10.2217/CLP.10.11. ISSN 1758-4299. PMC 2882156. PMID 20543887.
^Winn R, Harlan J, Nadir B, Harker L, Hildebrandt J (September 1983). "Thromboxane A2 mediates lung vasoconstriction but not permeability after endotoxin". Journal of Clinical Investigation. 72 (3): 911–918. doi:10.1172/jci111062. ISSN 0021-9738. PMC 1129256. PMID 6886010.
ThromboxaneA2 (TXA2) is a type of thromboxane that is produced by activated platelets during hemostasis and has prothrombotic properties: it stimulates...
Thromboxane is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxaneA2 and thromboxane B2. The distinguishing...
its preferred endogenous ligand thromboxaneA2. The gene responsible for directing the synthesis of the thromboxane receptor, TBXA2R, is located on human...
Thromboxane B2 (TXB2) is an inactive metabolite/product of thromboxaneA2. It is almost completely cleared in the urine. It itself is not involved in...
inhibitors. Low-dose aspirin use irreversibly blocks the formation of thromboxaneA2 in platelets, producing an inhibitory effect on platelet aggregation...
endoperoxide prostaglandin PGH2 first prepared in 1975, and acts as a thromboxaneA2 (TP) receptor agonist. It potently stimulates TP receptor-mediated,...
Low-dose, long-term aspirin use irreversibly blocks the formation of thromboxaneA2 in platelets, producing an inhibitory effect on platelet aggregation...
prostaglandins (which are mediators of pain, inflammation, and fever) and to thromboxaneA2 (which stimulates platelet aggregation, leading to the formation of...
phospholipase-A2, then brought to either the cyclooxygenase pathway or the lipoxygenase pathway. The cyclooxygenase pathway produces thromboxane, prostacyclin...
PMID 8542839. Lees P, Ewins CP, Taylor JB, Sedgwick AD (1987). "Serum thromboxane in the horse and its inhibition by aspirin, phenylbutazone and flunixin"...
that high-dose naproxen induced near-complete suppression of platelet thromboxane throughout the dosing interval and appeared not to increase cardiovascular...
concentrations) inhibits the production of prostaglandins and the production of thromboxaneA2, a platelet activator. COX-1 is traditionally defined as a constitutively...
99.1) that is responsible for biosynthesis of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member...
and thromboxaneA2. Adenosine diphosphate (ADP) attracts more platelets to the affected area, serotonin is a vasoconstrictor and thromboxaneA2 assists...
upon by: Prostacyclin synthase to create prostacyclin Thromboxane-A synthase to create thromboxaneA2 and 12-(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid...
is a precursor in the formation of leukotrienes, prostaglandins, and thromboxanes. Together with omega-3 fatty acids and other omega-6 fatty acids, arachidonic...
smooth muscle cells. However, aggregating platelets also stimulate thromboxaneA2 and serotonin which can induce contraction of the smooth muscle cells...
Seratrodast (development name, AA-2414; marketed originally as Bronica) is a thromboxaneA2 (TXA2) receptor (TP receptor) antagonist used primarily in the treatment...
counteracts any increase in cytosolic calcium levels that would result from thromboxaneA2 (TXA2) binding (leading to platelet activation and subsequent coagulation)...
leukotrienes (also pro-inflammatory autacoids). It also may inhibit phospholipase A2, which may be relevant to its mechanism of action. These additional actions...
the precursor to some prostaglandins, leukotrienes (LTA, LTB, LTC), thromboxane (TXA) and the N-acylethanolamine (NAE) arachidonoylethanolamine (AEA:...
activation: Platelet activators, such as platelet activating factor and thromboxaneA2, activate platelets in the bloodstream, leading to attachment of platelets'...
Global Information
verify (what is 
?)
