Before the fertilized ovum reaches the uterus, the mucous membrane of the body of the uterus undergoes important changes and is then known as the decidua. The thickness and vascularity of the mucous membrane are greatly increased; its glands are elongated and open on its free surface by funnel-shaped orifices, while their deeper portions are tortuous and dilated into irregular spaces. The interglandular tissue is also increased in quantity, and is crowded with large round, oval, or polygonal cells, termed decidual cells.[1] Their enlargement is due to glycogen and lipid accumulation in the cytoplasm allowing these cells to provide a rich source of nutrition for the developing embryo. Decidual cells are also thought to control the invasion of the endometrium by trophoblast cells.[2]
Experimentally, human endometrial stromal cells can be decidualized in culture by using analogs of cAMP and progesterone. The cells will exhibit a decidualized phenotype and display upregulation of common decidualization markers such as prolactin and IGFBP1.[3]
^Kearns, M; Lala, PK (March 1983). "Life history of decidual cells: a review". American Journal of Reproductive Immunology. 3 (2): 78–82. doi:10.1111/j.1600-0897.1983.tb00219.x. PMID 6344664. S2CID 28020938.
^Li, H; Huang, Q; Liu, Y; Garmire, LX (December 2020). "Single cell transcriptome research in human placenta". Reproduction. 160 (6): R155–R167. doi:10.1530/REP-20-0231. PMC 7707799. PMID 33112783. S2CID 225336002.
^Gellersen, Birgit; Brosens, Ivo; Brosens, Jan (2007-11-01). "Decidualization of the Human Endometrium: Mechanisms, Functions, and Clinical Perspectives". Seminars in Reproductive Medicine. 25 (6): 445–453. doi:10.1055/s-2007-991042. ISSN 1526-8004. PMID 17960529.[permanent dead link]
changes to cells of the endometrium in preparation for, and during, pregnancy. This includes morphological and functional changes (the decidual reaction)...
appearance, displaying large polygonal decidualcells in the stroma. These are enlarged endometrial stromal cells, which resemble epithelium (and are referred...
Ectopic decidua are decidualcells found outside inner lining of the uterus. This condition was first described in 1971 by Walker and the name 'ectopic...
is now known as the decidua, and it produces a great number of large decidualcells in its increased interglandular tissue. The blastomeres in the blastocyst...
of uteroplacental circulation, embryonic nutrition is derived from decidualcells and maternal blood pools that open up as a result of eroding activity...
and correlate with expansion of CD4+ regulatory T cells (Tregs). Decreased expansion and decidual accumulation of Treg cause pregnancy complications...
biochemical events lead to the softening and dilation of the cervix. Decidualcells, which play a nutritional role in the formation of the placenta, promote...
Suomalainen L, Parvinen M, Dunkel L (2000). "Estradiol acts as a germinal cell survival factor in the human testis in vitro". J Clin Endocrinol Metab. 85...
Natural killer cells, also known as NK cells or large granular lymphocytes (LGL), are a type of cytotoxic lymphocyte critical to the innate immune system...
In pathology, hypertrophic decidual vasculopathy, abbreviated HDV, is the histomorphologic correlate of gestational hypertension, as may be seen in intrauterine...
include BMP and Nodal. Elevated levels of Pcsk6 was detected in maternal decidualcells of the implantation site and the extraembryonic ectoderm. The regulation...
secreted by adaptive immune cells, more specifically CD4+ T helper 1 (Th1) cells, natural killer (NK) cells, and CD8+ cytotoxic T cells. The expression of type...
the Zika virus targets decidual macrophages, decidual fibroblasts, trophoblasts, Hofbauer cells, and mesenchymal stem cells due to their increased capacity...
infarcts are associated with vascular abnormalities, e.g. hypertrophic decidual vasculopathy, as seen in hypertension. Very large infarcts lead to placental...
new growth of the leaf; it consists of layers of cells that can separate from each other. The cells are sensitive to a plant hormone called auxin that...
proteomic investigation of the impact of preimplantation factor on human decidualcells". American Journal of Obstetrics and Gynecology. 202 (5): 459.e1–8....
form, and when examined under a microscope have large epithelioid decidual-like cells and large nucleoli. They produce high concentrations of equine chorionic...
placenta. A trophic factor, IL-15, for CD8+ memory T-cells is expressed by decidual stromal cells. The trafficking of maternal lymphocytes responding to...
organoids and mesenchymal cells or human embryonic stem cell-derived vascular organoids. Next, microglia-like cells derived from hiPS cells can be introduced...
Sanguansermsri, D., & Pongcharoen, S. (2008). Pregnancy immunology: decidual immune cells. Asian Pacific journal of allergy and immunology, 26(2-3), 171–181...
of the syncytiotrophoblast in the chorionic villi and in endometrial decidualcells at the uteroplacental interface. After week 10, the levels of trophinin...
uterus in a species-dependent manner. In humans, a thin layer of maternal decidual (endometrial) tissue comes away with the placenta when it is expelled from...
to the lining of the mother's uterus. This induces a decidual reaction, wherein the uterine cells proliferate and surround the embryo thus causing it to...
by which Granulosa cells differentiate into Luteal cells. Therefore, it can act as a good biomarker in relation to Granulosa cell differentiation status...
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