1. Daptomycin binds and inserts into the cell membrane. 2. It aggregates in the membrane. 3. It alters the shape of the membrane to form a hole, allowing ions in and out of the cell easily.
Identifiers
Symbol
N/A
TCDB
1.D.15
OPM superfamily
163
OPM protein
1t5n
Daptomycin, sold under the brand name Cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms.[4]
Daptomycin was removed from the World Health Organization's List of Essential Medicines in 2019.[7][8] The World Health Organization classifies daptomycin as critically important for human medicine.[9]
^"Daptomycin Use During Pregnancy". Drugs.com. 3 December 2019. Retrieved 28 August 2020.
^"Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
^"Cubicin 350 mg powder for solution for injection or infusion - Summary of Product Characteristics (SmPC)". (emc). 24 August 2018. Retrieved 28 August 2020.
^ ab"Cubicin- daptomycin injection, powder, lyophilized, for solution". DailyMed. 18 December 2018. Retrieved 28 August 2020.
^"Cubicin RF- daptomycin injection, powder, lyophilized, for solution". DailyMed. 18 December 2018. Retrieved 28 August 2020.
^"Cubicin". European Medicines Agency. 17 September 2018. Retrieved 28 August 2020.
^World Health Organization (2019). Executive summary: the selection and use of essential medicines 2019: report of the 22nd WHO Expert Committee on the selection and use of essential medicines. Geneva: World Health Organization. hdl:10665/325773. WHO/MVP/EMP/IAU/2019.05. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2019). The selection and use of essential medicines: report of the WHO Expert Committee on Selection and Use of Essential Medicines, 2019 (including the 21st WHO Model List of Essential Medicines and the 7th WHO Model List of Essential Medicines for Children). Geneva: World Health Organization. hdl:10665/330668. ISBN 9789241210300. ISSN 0512-3054. WHO technical report series;1021.
^World Health Organization (2019). Critically important antimicrobials for human medicine (6th revision ed.). Geneva: World Health Organization. hdl:10665/312266. ISBN 9789241515528.
Daptomycin, sold under the brand name Cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections...
cause meningitis, although rare and sepsis. The antibiotics linezolid, daptomycin and gentamicin, levofloxacin, and penicillin G are effective against the...
possible for microbes to become entirely tolerant of alcohol. Linezolid, daptomycin, tigecycline and the streptogramins (e.g. quinupristin/dalfopristin) can...
(Victoza®), and insulin detemir (Levemir®). The other two are the antibiotics daptomycin and polymyxin B. Lipidated peptides also have applications in other areas...
Staphylococcus aureus (MRSA) isolates and evaluated the in vitro activities of daptomycin and vancomycin while monitoring the isolates for the development of resistance...
the most important of these are: Chloramphenicol (from S. venezuelae) Daptomycin (from S. roseosporus) Fosfomycin (from S. fradiae) Lincomycin (from S...
clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid)...
monobactams, and carbapenems) and vancomycin. Also bactericidal are daptomycin, fluoroquinolones, metronidazole, nitrofurantoin, co-trimoxazole, telithromycin...
antibiotics, including aminoglycosides, carbapenems, cephalosporins, daptomycin and oritavancin. Enzymes conferring resistance to fosfomycin have also...
that have different mechanisms of action, like vancomycin, linezolid, daptomycin, and tigecycline. Ampicillin can be administered by mouth, an intramuscular...
and Lipopeptides - glycopeptidolipids, surfactin, iturnins, polymyxins, daptomycin". The LipidWeb. Retrieved 21 July 2019. Satyanarayana, U. (2002). Biochemistry...
molecule facially interact with the hydrophobic segment of MPs. Bacillomycin Daptomycin Echinocandins (e.g., caspofungin) Iturin A Mycosubtilin Surfactin Pepducins...
the first oxazolidinone 2001 – telithromycin, the first ketolide 2003 – daptomycin 2005 – tigecycline, the first glycylcycline 2005 – doripenem 2009 – telavancin...
methicillin-resistant Staphylococcus aureus with reduced susceptibility to linezolid, daptomycin or vancomycin. Ceftobiprole has also displayed potent activity against...
days) or 7 days of once daily daptomycin. finding that a single dose brilacidin was comparable to 7 days of daptomycin. The primary endpoint was clinical...
2019, Xellia partnered with Civica Rx to produce generic Vancomycin and Daptomycin. The partnership's stated aim is to remedy chronic drug shortages that...
including, in 2000, linezolid of the oxazolidinone class, and in 2003 daptomycin of the lipopeptide class. Several derivatives of vancomycin are currently...
found to be naturally resistant to many modern antibiotics, including daptomycin. The Denver Museum of Nature and Science filmed one of the first documentaries...
a combination of two streptogramins, not active against E. faecalis); daptomycin (Cubicin, a lipopeptide); and ceftobiprole (Zevtera, a 5th-generation...
"Bactericidal agents in the treatment of MRSA infections--the potential role of daptomycin". Journal of Antimicrobial Chemotherapy. 58 (6): 1107–17. doi:10.1093/jac/dkl393...
is a known human pathogen. For the few cases thus far, vancomycin or daptomycin has been used in tandem with rifampicin for a duration ranging from four...
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