The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells. DAB1 functions downstream of Reln in a signaling pathway
that controls cell positioning in the developing brain and during adult neurogenesis. It docks to the intracellular part of the Reelin very low density lipoprotein receptor (VLDLR) and apoE receptor type 2 (ApoER2) and becomes tyrosine-phosphorylated following binding of Reelin to cortical neurons. In mice, mutations of Dab1 and Reelin generate identical phenotypes. In humans, Reelin mutations are associated with brain malformations and mental retardation. In mice, Dab1 mutation results in the scrambler mouse phenotype.
With a genomic length of 1.1 Mbp for a coding region of 5.5 kb, DAB1 provides a rare example of genomic complexity, which will impede the identification of human mutations.
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028519 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly...
full knowledge of the mechanisms that control corticogenesis. The Reelin-DAB1 pathway is a well-defined pathway involved in corticogenesis. Cajal-Retzius...
that the mouse disabled homologue 1 (Dab1) gene is responsible for the phenotypes of these mutant mice, as Dab1 protein was absent (yotari) or only barely...
Scrambler is a spontaneous mouse mutant lacking a functional DAB1 gene, resulting in a phenotype resembling that seen in the reeler mouse. The strain was...
and limb ataxia with severe dysmetria in the lower extremities, mild dysmetria in the upper extremities, dysphagia, and abnormal ocular movements DAB1...
responses. Reelin modulates NMDA function through Src family kinases and DAB1. significantly enhancing LTP in the hippocampus. Src kinase enhances NMDA...
The CRK protein participates in the Reelin signaling cascade downstream of DAB1. Adapter molecule crk is a member of an adapter protein family that binds...
and CrkL in most neurons. Was used to show that Crk/CrkL lie downstream of DAB1] in the reelin signaling pathway. Scrambler mouse Inversion of cortical layers...
mouse Disabled 2(Dab2):implications for Reeling signaling 1p3r: Crystal structure of the phosphotyrosin binding domain(PTB) of mouse Disabled 1(Dab1)...
1051621 OBIS: 127079 Open Tree of Life: 396435 Plazi: EF613B30-BC7D-87C3-DAB1-EB94DDC08E58 WoRMS: 127079 ZooBank: DAD84740-4F60-4B06-B26A-0CCF276DB6DC...
mouse is an autosomal recessive mutant. It has a mutated disabled homolog 1 (Dab1) gene. This mutant mouse is recognized by unstable gait ("Yota-ru" in Japanese...
intracellular protein, Dab1, has a PI/PTB domain that interacts with the NPxY sequence found in the cytoplasmic tail of VLDLR. As a result, Dab1 is tyrosine phosphorylated...
North end of MS 25 overlap Module:Jctint/USA warning: Unused argument(s): dab1 13.1 21.1 MS 471 Bus. south – Fannin Northern terminus of MS 471 Bus Goshen...
680484 IUCN: 49830049 Open Tree of Life: 3622654 Plazi: 398B501E-6D83-03FC-DAB1-2134B291E13C WoRMS: 1012832 ZooBank: 4BC50D4C-05BE-4958-984F-85B8B8C0F0F0...
discussed in detail in this article. PTBs are protein domains that include NUMB, DAB1 and DAB2. Epsin and AP180 in the ANTH domain are other adaptor proteins that...
that Cul5 plays a role in Reelin signaling cascade, participating in the DAB1 degradation and thus ensuring the negative feedback mechanism of Reelin signaling...
(June 2018). "RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development". Molecular and Cellular Biology. 38 (12). doi:10...
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