Crystallographic structure of human biliverdin reductase A based on the PDB: 2H63 coordinates. The enzyme is displayed as a rainbow colored cartoon (N-terminus = blue, C-terminus = red) while the NADP cofactor is displayed as space-filling model (carbon = white, oxygen = red, nitrogen = blue, phosphorus = orange).
Identifiers
Symbol
BLVRA
Alt. symbols
BLVR
NCBI gene
644
HGNC
1062
OMIM
109750
RefSeq
NM_000712
UniProt
P53004
Other data
EC number
1.3.1.24
Locus
Chr. 7 p14-cen
Search for
Structures
Swiss-model
Domains
InterPro
biliverdin reductase B
Identifiers
Symbol
BLVRB
Alt. symbols
FLR
NCBI gene
645
HGNC
1063
OMIM
600941
RefSeq
NM_000713
UniProt
P30043
Other data
EC number
1.3.1.24
Locus
Chr. 19 q13.1-13.2
Search for
Structures
Swiss-model
Domains
InterPro
Biliverdin reductase, catalytic
crystal structure of a biliverdin reductase enzyme-cofactor complex
Identifiers
Symbol
Biliv-reduc_cat
Pfam
PF09166
InterPro
IPR015249
SCOP2
1lc0 / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Biliverdin reductase (BVR) is an enzyme (EC 1.3.1.24) found in all tissues under normal conditions, but especially in reticulo-macrophages of the liver and spleen. BVR facilitates the conversion of biliverdin to bilirubin via the reduction of a double bond between the second and third pyrrole ring into a single bond.
There are two isozymes in humans, each encoded by its own gene, biliverdin reductase A (BLVRA) and biliverdin reductase B (BLVRB).
and 20 Related for: Biliverdin reductase information
Biliverdinreductase (BVR) is an enzyme (EC 1.3.1.24) found in all tissues under normal conditions, but especially in reticulo-macrophages of the liver...
The production of biliverdin from heme is the first major step in the catabolic pathway, after which the enzyme biliverdinreductase performs the second...
Biliverdinreductase B is a protein that in humans is encoded by the BLVRB gene. The BLVRB gene was localized to chromosome 19, the specific region being...
its damaging effects. In the second reaction, biliverdin is converted to bilirubin by biliverdinreductase (BVR): Bilirubin is transported into the liver...
on NADPH-cytochrome P450 reductase and oxygen to cleave heme/porphyrin ring at the alpha-methene bridge to form biliverdin (or verdoglobin if the heme...
color tetrapyrrole pigment called bilirubin by cytosolic enzyme biliverdinreductase. This bilirubin is "unconjugated", "free", or "indirect" bilirubin...
heme to form biliverdin, carbon monoxide, and ferrous iron. The biliverdin is subsequently converted to bilirubin by biliverdinreductase. Heme oxygenase...
to biliverdin and well as carbon monoxide that is exhaled. Biliverdin is then converted to bilirubin with biliverdinreductase. As high biliverdin levels...
generated from the degradation of heme, which is first degraded through biliverdin to bilirubin. Bilirubin is then excreted as bile, which is further degraded...
heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdinreductase, and carbon monoxide, a putative neurotransmitter...
Bilindione-10-Thiol-Adduct as a Model for the Reduction Step of the BiliverdinReductase System. Monatsh. Chem. 122, 319 (1991) U. Wagner, C. Kratky, H. Falk...
Ennis O, Mantle TJ (1 Jun 1996). "Evidence that biliverdin-IX beta reductase and flavin reductase are identical". Biochem. J. 316 (2): 385–7. doi:10...
macrophages to Biliverdin and ferrous ions by the enzyme HO-1. Biliverdin formed further gets converted to Bilirubin and carbon monoxide. Biliverdin and Bilirubin...
containing pyrroles include vitamin B12, bile pigments like bilirubin and biliverdin, and the porphyrins of heme, chlorophyll, chlorins, bacteriochlorins,...
1 (HCP1). Heme is then catabolized by microsomal heme oxygenase into biliverdin, releasing Fe2+. These intestinal lining cells can then either store the...
activity by autophosphorylation. Inhibited by the heme-degradation products biliverdin and bilirubin. Induced by oxidative stress generated by arsenite treatment...
is an enzyme that catalyzes the breakdown of heme into the antioxidant biliverdin, the anti-inflammatory agent carbon monoxide, and iron. HO-1 is a NRF2...
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