Dangerously low blood pressure due to damage from an organ infection
Medical condition
Septic shock
Sepsis is one of the most common causes of death in critically ill patients in Intensive Care Units. Oil by Gabriël Metsu.
Specialty
Infectious disease
Thrombocytopenia with purpura on right hand in patient with septic shock
Septic shock is a potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) defines septic shock as a subset of sepsis in which particularly profound circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than with sepsis alone. Patients with septic shock can be clinically identified by requiring a vasopressor to maintain a mean arterial pressure of 65 mm Hg or greater and having serum lactate level greater than 2 mmol/L (>18 mg/dL) in the absence of hypovolemia. This combination is associated with hospital mortality rates greater than 40%.[1]
The primary infection is most commonly caused by bacteria, but also may be by fungi, viruses or parasites. It may be located in any part of the body, but most commonly in the lungs, brain, urinary tract, skin or abdominal organs.[2] It can cause multiple organ dysfunction syndrome (formerly known as multiple organ failure) and death.[3]
Frequently, people with septic shock are cared for in intensive care units. It most commonly affects children, immunocompromised individuals, and the elderly, as their immune systems cannot deal with infection as effectively as those of healthy adults. The mortality rate from septic shock is approximately 25–50%.[3]
^Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. (February 2016). "The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)". JAMA. 315 (8): 801–10. doi:10.1001/jama.2016.0287. PMC 4968574. PMID 26903338.
^Jui J (2011). "Ch. 146: Septic Shock". In Tintinalli JE, Stapczynski JS, Ma OJ, Cline DM, et al. (eds.). Tintinalli's Emergency Medicine: A Comprehensive Study Guide (7th ed.). New York: McGraw-Hill. pp. 1003–14. Retrieved December 11, 2012 – via AccessMedicine.
^ abKumar V, Abbas A, Fausto N, et al., eds. (2007). Robbins Basic Pathology (8th ed.). Saunders, Elsevier. pp. 102–3. ISBN 9781416029731.
Septicshock is a potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously...
high blood lactate, or low urine output may suggest poor blood flow. Septicshock is low blood pressure due to sepsis that does not improve after fluid...
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most common cause is sepsis leading to a type of distributive shock called septicshock, a condition that can be fatal. Elbers and Ince have identified...
that causes fever). In severe cases, LPS can play a role in causing septicshock. In lower levels and over a longer time period, there is evidence LPS...
sometimes associated with septicshock. With prompt treatment, the prognosis is excellent. Pericarditis can appear, either as a septic pericarditis with grave...
approximately 20 hours.[citation needed] Fluid replacement in patients with septicshock can be divided into four stages as shown below: Resuscitation phase -...
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limbs Death Liver or kidney failure Heart problems Respiratory distress Septicshock Other abnormalities may occur depending on the case During menstruation:...
Common causes of distributive shock include sepsis, anaphylaxis, and head or spinal cord injury (neurogenic shock). Septicshock is typically caused by an...
to infected sites. Plasma hyaluronic acid is elevated in sepsis and septicshock and correlate with disease severity, but the effect on mortality shows...
cardiogenic shock. Finally, other causes should be considered that are not related to trauma or blood loss. In the undifferentiated patient with shock, septic shock...
2008. Allen was diagnosed with non-Hodgkin lymphoma in 2009. He died of septicshock related to cancer on October 15, 2018, at the age of 65. Shortly after...
helpful as well. Septic treatment protocol and diagnostic tools have been created due to the potentially severe outcome septicshock. For example, the...
2016). "The Third International Consensus Definitions for Sepsis and SepticShock (Sepsis-3)". JAMA. 315 (8): 801–10. doi:10.1001/jama.2016.0287. PMC 4968574...
of severe heart failure or cardiogenic shock. In newborn babies it may be used for hypotension and septicshock. A dopamine molecule consists of a catechol...
as fever and skin changes, to severe with pneumonia, abscesses, and septicshock that could cause death. Approximately 10% of people with melioidosis...
norepinephrine-resistant septicshock although, 2021 Surviving Sepsis Guidelines recommend against its use for adults with septicshock and hepatorenal syndrome...
Vasodilatory shock, vasogenic shock, or vasoplegic shock is a medical emergency belonging to shock along with cardiogenic shock, septicshock, allergen-induced...
ill patients with septicshock because it could increase mortality. However, other authors continue to defend etomidate's use for septic patients because...
rate of administering intravenous fluids. In patients with sepsis or septicshock they are more susceptible to experience acute kidney injury (AKI) and...
vascular leakage of fluid and cells, and ultimately hypovolemic shock and septicshock.[citation needed] Various techniques may be used for the direct...
are acute respiratory distress syndrome, asthma, acute anaphylaxis, septicshock, and disseminated intravascular coagulation. The term is generally not...
accompanying organ failure (e.g. liver failure and kidney failure), SIRS, septicshock, and metabolic acidosis (see Kussmaul breathing, or in general any labored...
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