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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Cucurbitacin E is a biochemical compound from the family of cucurbitacins. These are found in plants which are member of the family Cucurbitaceae, most of them coming from traditional Chinese medicinal plants, but also in other plants such as pumpkins and gourds.
Cucurbitacin E is a highly oxidated steroid consisting of a tetracyclic triterpene. Specific modifications in this molecule under certain conditions can form other types of cucurbitacins such as cucurbitacin I, J, K and L.
As of 2020[update], it is being investigated for its potential biological effects. Cucurbitacin E has been found to increase activity of anti-cancer drugs in certain types of cancers.[1] It selectively increases chemosensitivity of nutrient receptors, on or inside cancer cells, to anti-cancer drug molecules, thereby decreasing binding of the nutrients to cancer cells, and decreasing their growth, leading to selective cell death of cancer cells.[1]
Cucumbers belong to the family CucurbitaceaeWatermelons are a rich source of cucurbitacin E
^ abYang, Peng; Liu, Wen; Fu, Rong; Ding, Guo-bin; Amin, Sajid; Li, Zhuoyu (2020-12-02). "Cucurbitacin E Chemosensitizes Colorectal Cancer Cells via Mitigating TFAP4/Wnt/β-Catenin Signaling". Journal of Agricultural and Food Chemistry. 68 (48): 14148–14160. doi:10.1021/acs.jafc.0c05551. ISSN 0021-8561. PMID 33205649. S2CID 227038679.
Cucurbitacins are a class of biochemical compounds that some plants – notably members of the pumpkin and gourd family, Cucurbitaceae – produce and which...
CucurbitacinE is a biochemical compound from the family of cucurbitacins. These are found in plants which are member of the family Cucurbitaceae, most...
plant family, but also cucurbitacins, which are better known as chemical defenses in the Cucurbitaceae plant family. Cucurbitacins from Iberis amara have...
striped cucumber beetle is unique in that it is resistant to a chemical, cucurbitacin, that is found in plants and serves as a defense mechanism against herbivores...
Cucurbitacin D is a plant triterpene first identified in plants in the family Cucurbitaceae. In preliminary in vitro studies, it has shown inhibitory properties...
cucurbitacin and plantainoside B. Lansdown, R.V.; Knees, S.G.; Patzelt, A. (2013). "Bacopa monnieri". IUCN Red List of Threatened Species. 2013: e.T164168A17722668...
include triterpenoid saponins and the seeds have been reported with six cucurbitacin glycosides. as well as 28-30 amino acids. The Moche culture often depicted...
Elaterium is the cucurbitacin extract used in ancient history as a purgative in folk medicine. Extracted from the juice of the fruit of E. elaterium, elaterium...
occasionally used in sweeter cooking. Zucchini occasionally contain toxic cucurbitacins, making them extremely bitter, and causing severe gastero-enteric upsets...
grow in sales by 13% annually and reach $631 million from 2020 to 2024. Cucurbitacin Cucurbitin Egusi List of edible seeds List of squash and pumpkin dishes...
(TAK-279), TYK2 inhibitor for the treatment of psoriatic arthritis. Cucurbitacin I (JSI-124). CHZ868 — a type II JAK2 inhibitor for use in myeloproliferative...
such as (E,Z)-nona-2,6-dienal, and the cis- and trans- isomers of 2-nonenal. The slightly bitter taste of cucumber rind results from cucurbitacins. In general...
7/6/17 Bittner, M., Poyser, K.A., Poyser J.P., Silva M. and Weldt, E. 1973 Cucurbitacins and aromatic compounds from Crinodendron hookerianum. Phytochemistry...
Karavilagenin E is a chemical compound found in the Balsam apple vine (Momordica balsamina). It is a cucurbitane-type triterpenoid, related to cucurbitacin. Karavilagenin...
plants are poisonous, some highly so, and may be fatal if ingested. Cucurbitacin glycosides are primarily responsible for the plants' bitterness and emetic...
feed. Additionally, other wild species have bitter fruit containing cucurbitacin. C. colocynthis (L.) Schrad. ex Eckl. & Zeyh., C. rehmii De Winter, and...
July 2023. Retrieved 18 September 2023. Guttman-Yassky E, Pavel AB, Diaz A, Zhang N, Del Duca E, Estrada Y, et al. (April 2022). "Ritlecitinib and brepocitinib...
summer moisture. The fruit and foliage are toxic due to the presence of cucurbitacin. The plant is toxic to humans as well as to horses, sheep, cattle and...
ovate. The seeds are about 6 mm. The plant contains dendrosycin, an iso-cucurbitacin with an unusual ring formation. Described in 1882 by Isaac Bayley Balfour...
cultivated varieties, there are occasional reports of cucurbitacin causing illness in humans. Cucurbitacin is also used as a lure in insect traps. As an example...
Archived from the original on 17 October 2013. Retrieved 6 June 2014. Rudzki E; Grzywa Z (October 1977). "Dermatitis from Arnica montana". Contact Dermatitis...
high concentrations of tetracyclic triterpenoid compounds known as cucurbitacins. They impart a bitter flavor which serve as a natural pest deterrent...
Cucurbitaceae, gourds contain cucurbitacins that are known to be cytotoxic at a high concentration. The tetracyclic triterpenoid cucurbitacins present in fruits and...
steroid hormone receptors. Important sub-classes include sterols and cucurbitacins. Triterpenoid saponins are triterpenes which belong to the saponin group...
the Pacific Islands and in Australia. The blades of the plant contain cucurbitacins, which are poisonous to some animals, and some of them are among the...
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