Cosegregation is the transmission to the next generation, of two or more genes in proximity on the same chromosome. Their closeness means that they are genetically linked.[1] It may also represent an interaction estimation probability between any number of loci.
A. Nucleus, B. Nuclear Profile - Thin slice of Nucleus, C. Loci - Parts of a target gene found within the Nuclear Profile
Interaction probability is determined using specified parts of a target gene (loci) and a group of nuclear profiles (NPs).[2] The picture to the right serves to provide visual aid as to how a slice (NP) is taken from the nucleus and loci are searched for within the NP. Cosegregation used within other mathematical models (SLICE[3] and normalized linkage disequilibrium) assist in rendering 3-D visualizations as a smaller process of genome architecture mapping (GAM). These renderings help determine genomic density and radial position.
Articles Using Co-segregation Methodologies
Title
Description
Complex multi-enhancer contacts captured by Genome Architecture Mapping (GAM).[3]
Co-segregation between a pair of loci helped in this study to quantify Normalized Linkage Disequilibrium.
A simple method for cosegregation analysis to evaluate the pathogenicity of unclassified variants; BRCA1 and BRCA2 as an example.[4]
Using co-segregation analysis along with a multifactorial approach resulted in highly conclusive results when attempting to classify unclassified variants.
Considerations in assessing germline variant pathogenicity using co-segregation analysis.[5]
This article found that utilizing Bayes factor co-segregation analysis, along with a strong penetrance model, will result with higher accuracy than meiosis counting.
^"Cosegregation". cancer.gov. Retrieved 4 May 2023.
^Wrighton, Katharine H. (May 2017). "Zooming in on nuclear organization". Nature Reviews Molecular Cell Biology. 18 (5): 275. doi:10.1038/nrm.2017.28. PMID 28327555. S2CID 3453730.
^ abBeagrie, Robert A.; Scialdone, Antonio; Schueler, Markus; Kraemer, Dorothee C. A.; Chotalia, Mita; Xie, Sheila Q.; Barbieri, Mariano; de Santiago, Inês; Lavitas, Liron-Mark; Branco, Miguel R.; Fraser, James; Dostie, Josée; Game, Laurence; Dillon, Niall; Edwards, Paul A. W.; Nicodemi, Mario; Pombo, Ana (March 2017). "Complex multi-enhancer contacts captured by genome architecture mapping". Nature. 543 (7646): 519–524. Bibcode:2017Natur.543..519B. doi:10.1038/nature21411. PMC 5366070. PMID 28273065.
^Mohammadi, Leila; Vreeswijk, Maaike P; Oldenburg, Rogier; van den Ouweland, Ans; Oosterwijk, Jan C; van der Hout, Annemarie H; Hoogerbrugge, Nicoline; Ligtenberg, Marjolijn; Ausems, Margreet G; van der Luijt, Rob B; Dommering, Charlotte J; Gille, Johan J; Verhoef, Senno; Hogervorst, Frans B; van Os, Theo A; Gómez García, Encarna; Blok, Marinus J; Wijnen, Juul T; Helmer, Quinta; Devilee, Peter; van Asperen, Christi J; van Houwelingen, Hans C (29 June 2009). "A simple method for co-segregation analysis to evaluate the pathogenicity of unclassified variants; BRCA1 and BRCA2 as an example". BMC Cancer. 9: 211. doi:10.1186/1471-2407-9-211. PMC 2714556. PMID 19563646.
^Belman, Sophie; Parsons, Michael T.; Spurdle, Amanda B.; Goldgar, David E.; Feng, Bing-Jian (December 2020). "Considerations in assessing germline variant pathogenicity using cosegregation analysis". Genetics in Medicine. 22 (12): 2052–2059. doi:10.1038/s41436-020-0920-4. PMID 32773770. S2CID 221084291.
Cosegregation is the transmission to the next generation, of two or more genes in proximity on the same chromosome. Their closeness means that they are...
cats segregated for melanism. The domestic cat family demonstrated a cosegregation between the ASIP allele and coat black coloration. Cats have excellent...
the cosegregation graph. However, if the simple mean is used, then the threshold may be higher than intended. This is because the cosegregation value...
HH, Bale AE, McBride OW, Nebert DW (Apr 1991). "Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP". American Journal...
Tunstead, James R.; Lansita, Janice A.; Merok, Joshua R. (December 2002). "Cosegregation of Chromosomes Containing Immortal DNA Strands in Cells That Cycle with...
Porteous DJ, Muir WJ (Aug 2001). "Schizophrenia and affective disorders—cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed...
Porteous DJ, Muir WJ (Aug 2001). "Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed...
et al. (1992). "Autosomal dominant retinitis pigmentosa (adRP; RP6): cosegregation of RP6 and the peripherin-RDS locus in a late-onset family of Irish...
(fibrofolliculomas, trichodiscomas and acrochordons). Subsequently, cosegregation of kidney neoplasms with BHD cutaneous lesions was observed in 3 families...
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