Protein-coding gene in the species Homo sapiens
ATP1A2 Identifiers Aliases ATP1A2 , FHM2, MHP2, ATPase Na+/K+ transporting subunit alpha 2, DEE98, FARIMPDExternal IDs OMIM: 182340; MGI: 88106; HomoloGene: 47947; GeneCards: ATP1A2; OMA:ATP1A2 - orthologs Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.2 Start 160,115,759 bp[1] End 160,143,591 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.6 cM Start 172,099,276 bp[2] End 172,125,631 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus trigeminal ganglion superior vestibular nucleus ventral tegmental area endothelial cell Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii paraflocculus of cerebellum pars reticulata subthalamic nucleus
Top expressed in ciliary body iris substantia nigra ankle medial vestibular nucleus sternocleidomastoid muscle medial geniculate nucleus digastric muscle olfactory tubercle globus pallidus
More reference expression data
BioGPS More reference expression data
Gene ontology Molecular function
steroid hormone binding
nucleotide binding
chaperone binding
potassium ion binding
sodium ion binding
P-type sodium:potassium-exchanging transporter activity
metal ion binding
ATPase-coupled cation transmembrane transporter activity
ATPase activity
protein binding
hydrolase activity
ATP binding
P-type potassium transmembrane transporter activity
Cellular component
cytoplasm
extracellular vesicle
integral component of membrane
endosome
membrane
intercalated disc
T-tubule
myelin sheath
plasma membrane
dendritic spine
synapse
sodium:potassium-exchanging ATPase complex
caveola
neuron projection
sarcolemma
Biological process
visual learning
cellular response to steroid hormone stimulus
regulation of muscle contraction
regulation of cardiac conduction
cardiac muscle contraction
regulation of smooth muscle contraction
sodium ion transport
regulation of the force of heart contraction
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
negative regulation of heart contraction
cellular sodium ion homeostasis
adult locomotory behavior
sodium ion export across plasma membrane
negative regulation of striated muscle contraction
cell communication by electrical coupling involved in cardiac conduction
response to nicotine
response to glycoside
ion transport
cellular potassium ion homeostasis
regulation of blood pressure
regulation of respiratory gaseous exchange by nervous system process
potassium ion transport
regulation of cardiac muscle cell contraction
ion transmembrane transport
ATP metabolic process
cellular response to mechanical stimulus
regulation of striated muscle contraction
membrane repolarization
negative regulation of calcium ion transmembrane transport
regulation of vasoconstriction
neurotransmitter uptake
negative regulation of calcium:sodium antiporter activity
locomotion
regulation of glutamate uptake involved in transmission of nerve impulse
regulation of synaptic transmission, glutamatergic
relaxation of cardiac muscle
membrane depolarization during cardiac muscle cell action potential
negative regulation of cytosolic calcium ion concentration
potassium ion import across plasma membrane
establishment or maintenance of transmembrane electrochemical gradient
transport
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 1: 160.12 – 160.14 Mb Chr 1: 172.1 – 172.13 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Sodium/potassium-transporting ATPase subunit alpha-2 is a protein which in humans is encoded by the ATP1A2 gene.[5] [6]
^ a b c GRCh38: Ensembl release 89: ENSG00000018625 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007097 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "ATP1A2 - Sodium/potassium-transporting ATPase subunit alpha-2 precursor - Homo sapiens (Human) - ATP1A2 gene & protein". www.uniprot.org . Retrieved 9 April 2022 .
^ "Entrez Gene: ATP1A2 ATPase, Na+ /K+ transporting, alpha 2 (+) polypeptide".
Last Update: 2023-10-22T20:31:15Z
ATPase subunit alpha-2 is a protein which in humans is encoded by the ATP1A2 gene. The protein encoded by this gene belongs to the family of P-type cation...
Word Count : 1269
Last Update: 2024-04-26T16:24:24Z
less than 25% of cases, is caused by mutations in the Na+ /K+ -ATPase gene ATP1A2 . FHM3 is a rare subtype of FHM and is caused by mutations in a sodium channel...
Word Count : 4222
Last Update: 2024-02-27T23:05:48Z
usually take two main conformations, E1 and E2. Na+/K+ transporting: ATP1A1, ATP1A2 , ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP1B4 Ca++ transporting: ATP2A1...
Word Count : 2143
Last Update: 2023-12-26T05:54:48Z
suffer from Hemiplegic migraines may have mutations of the CACNA1A and the ATP1A2 genes. The ICHD classification and diagnosis of migraine distinguish 6 subtypes...
Word Count : 725
Last Update: 2024-05-18T14:11:15Z
ATP1A3. A small number of cases seem to be caused by a mutation in the ATP1A2 gene. Where the mutation is inherited, it has the autosomal dominant pattern...
Word Count : 2581
Last Update: 2023-12-25T03:28:16Z
childhood: no mutations in the second familial hemiplegic migraine gene ATP1A2 ". Neuropediatrics. 35 (5): 293–6. doi:10.1055/s-2004-821082. PMID 15534763...
Word Count : 1419
Last Update: 2023-08-17T16:35:51Z
cases with permanent neurological deficits have also been noted. CACNA1A, ATP1A2 and SCNA1 are genes associated with hemipeligic migraines, although many...
Word Count : 444
Last Update: 2023-03-03T20:57:38Z
"Migrainous vertigo: mutation analysis of the candidate genes CACNA1A, ATP1A2 , SCN1A, and CACNB4". Headache. 46 (7): 1136–41. doi:10.1111/j.1526-4610...
Word Count : 1221
Last Update: 2024-05-09T15:43:25Z
Alström syndrome; 203800; ALMS1 Alternating hemiplegia of childhood; 104290; ATP1A2 Alveolar capillary dysplasia with misalignment of pulmonary veins; 265380;...
Word Count : 18877