Controlled internal drug release (CIDR) devices are used in livestock for the synchronization of estrus. They are T-shaped devices with a silicone-coated nylon core.[1] The silicone coating is impregnated with progesterone.[2] CIDRs are inserted intra-vaginally using a specialized applicator. The flexible wings collapse for facilitated insertion and expand once placed appropriately within the vagina.[2] The expansion of the wings retains its position; CIDRs have very high retention rates that may exceed 97%.[3] A thin nylon tail remains exteriorized and is used for removal.[2]
Once inserted, CIDRs provide slow-release administration of progesterone, which artificially extends the luteal phase.[1] Plasma progesterone levels rapidly increase upon insertion, and remain relatively consistent while in place.[4] Following CIDR removal, progesterone levels decrease rapidly.[3] Occasionally, vaginal irritation may occur. This is normal and does not impact the effectiveness of the device or the animal’s performance.[3]
There are several types of CIDRs available, including CIDR-B for cattle, CIDR-S for sheep and CIDR-G for goats. CIDRs are similar to the progesterone-releasing intravaginal device (PRID), also used for synchronization of estrous cycles in livestock.
^ abCarlson, K.M.; Pohl, H.A.; Marcek, J.M.; Muser, R.K.; Wheaton, J.E. (1989). "Evaluation of progesterone controlled internal drug release dispensers for synchronization of estrus in sheep". Animal Reproduction Science. 18 (1–3): 205–218. doi:10.1016/0378-4320(89)90022-5.
^ abcMapletoft, J.R; Martínez, M.F.; Colazo, M.G.; Kastelic, J.P. (2003). "The use of controlled internal drug release devices for the regulation of bovine reproduction". Journal of Animal Science. 81 (14): E28–E36.
^ abcEric Grant. 2006. Understanding CIDR. National Association of Animal Breeders. Feb 1, 2006. Retrieved March 20, 2012, from Beef Magazine: http://beefmagazine.com/mag/beef_understanding_cidr
^Wheaton, J.E; Carlson, K.M.; Windels, H.F.; Johnston, L.J. (1993). "CIDR: A new progesterone-releasing intravaginal device for induction of estrus and cycle control in sheep and goats". Animal Reproduction Science. 33 (1–4): 127–141. doi:10.1016/0378-4320(93)90111-4.
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