Change in the shape of a macromolecule, often induced by environmental factors
Conformational changes can elicit the motion of a protein complex. Kinesin walking on a microtubule is a molecular biological machine using protein domain dynamics on nanoscales
Main article: Protein dynamics
In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors.
A macromolecule is usually flexible and dynamic. Its shape can change in response to changes in its environment or other factors; each possible shape is called a conformation, and a transition between them is called a conformational change. Factors that may induce such changes include temperature, pH, voltage, light in chromophores, concentration of ions, phosphorylation, or the binding of a ligand. Transitions between these states occur on a variety of length scales (tenths of Å to nm) and time scales (ns to s),
and have been linked to functionally relevant phenomena such as allosteric signaling[1] and enzyme catalysis.[2]
^Bu Z, Callaway DJ (2011). "Proteins move! Protein dynamics and long-range allostery in cell signaling". Protein Structure and Diseases. Vol. 83. pp. 163–221. doi:10.1016/B978-0-12-381262-9.00005-7. ISBN 9780123812629. PMID 21570668. {{cite book}}: |journal= ignored (help)
^
Fraser JS, Clarkson MW, Degnan SC, Erion R, Kern D, Alber T (December 2009). "Hidden alternative structures of proline isomerase essential for catalysis". Nature. 462 (7273): 669–73. Bibcode:2009Natur.462..669F. doi:10.1038/nature08615. PMC 2805857. PMID 19956261.
and 24 Related for: Conformational change information
In biochemistry, a conformationalchange is a change in the shape of a macromolecule, often induced by environmental factors. A macromolecule is usually...
between the biological activity and the conformation or conformationalchanges of a biomolecule Equine conformation evaluates the degree of correctness of...
spontaneous conformationalchange of this serpin to the latent conformation. Certain non-inhibitory serpins also use the serpin conformationalchange as part...
proteins, the spike protein in its pre-fusion conformation is in a metastable state. A dramatic conformationalchange is triggered to induce the heptad repeats...
that a conformationalchange in one induces a similar change in the others. Thus, all enzyme subunits do not necessitate the same conformation. Moreover...
induces a conformationalchange and activates the receptor. This conformationalchange is often the result of small changes in charge or changes in protein...
structure. Conformational ensembles have been devised as a way to provide a more accurate and 'dynamic' representation of the conformational state of intrinsically...
developed the binding change, or flip-flop, mechanism theory, which postulated that ATP synthesis is dependent on a conformationalchange in ATP synthase generated...
detect light energy, the chromophore is the moiety that causes a conformationalchange in the molecule when hit by light. Just like how two adjacent p-orbitals...
enzymes that change their conformational ensemble upon binding of an effector (allosteric modulator) which results in an apparent change in binding affinity...
isomerisation, changing from the 11-cis-retinal to the all-trans-retinal configuration. Opsin therefore undergoes a conformationalchange to metarhodopsin...
structure of LeuT in the inward-open conformation subsequently demonstrated that the major component of the conformationalchange represents movement of the bundle...
interact with each other. Garvalov et al. propose that TES exists in two conformational states: A 'closed' state where the N & C halves of TES interact, obscuring...
molecular chaperones facilitate changes in shape (conformationalchange) of macromolecules in response to changes in environmental factors like temperature...
subunits of multimeric proteins have two conformational states. The binding of the ligand causes conformationalchange in the other subunits of the multimeric...
regulatory domain. When tetracycline binds this cavity, it causes a conformationalchange that affects the DNA-binding domain so that TetR is no longer able...
are held in a high-energy conformation. When the local pH drops, the protein undergoes an energetically favorable conformational rearrangement that enables...
exporters is greater in the inward-facing conformation. A model that describes the conformationalchanges in the nucleotide-binding domain (NBD) as a...
be modelled due to its conformational flexibility, and amino acids P9-P14 are not seen in this structure. This conformational flexibility indicates an...
signal either by binding to a specific chemical or by undergoing a conformationalchange when interacting with physical agents. It is the specificity of...
are usually referred to as "conformations", and transitions between them are called conformationalchanges. Such changes are often induced by the binding...
remaining three monomers in the tetramer, where it induces a similar conformationalchange in the other heme sites such that binding of oxygen to these sites...
an intermediate plasminogen structure suggests that plasminogen conformationalchange to the open form is initiated through KR-5 transiently peeling away...
Global Information