TetR as a homodimer: Each monomer is shown in purple or salmon. The helix-turn-helix motif is shown in deep red.
Tet Repressor proteins (otherwise known as TetR) are proteins playing an important role in conferring antibiotic resistance to large categories of bacterial species.
Tetracycline (Tc) is a broad family of antibiotics to which bacteria have evolved resistance. Tc normally kills bacteria by binding to the bacterial ribosome and halting protein synthesis. The expression of Tc resistance genes is regulated by the repressor TetR. TetR represses the expression of TetA, a membrane protein that pumps out substances toxic to the bacteria like Tc, by binding the tetA operator.[1] In Tc-resistant bacteria, TetA will pump out Tc before it can bind to the ribosome because the repressive action of TetR on TetA is halted by binding of Tc to TetR.[1] Therefore, TetR may have an important role in helping scientists to better understand mechanisms of antibiotic resistance and how to treat antibiotic resistant bacteria. TetR is one of many proteins in the TetR protein family, which is so named because TetR is the most well characterized member.[2]
TetR is used in artificially engineered gene regulatory networks because of its capacity for fine regulation of promoters. In the absence of Tc or analogs like ATc, basal expression of TetR-regulated promoters is low, but expression rises sharply in the presence of even a minute quantity of Tc. The tetA gene is also present in the widely used E. coli cloning vector pBR322, where it is often referred to by the name of its tetracycline-resistance phenotype, TetR, not to be confused with TetR.[3]
^ abRamos JL, Martínez-Bueno M, Molina-Henares AJ, Terán W, Watanabe K, Zhang X, et al. (June 2005). "The TetR family of transcriptional repressors". Microbiology and Molecular Biology Reviews. 69 (2): 326–56. doi:10.1128/mmbr.69.2.326-356.2005. PMC 1197418. PMID 15944459.
^"InterPro". www.ebi.ac.uk. Retrieved 2020-08-06.
^Allard JD, Bertrand KP (September 1992). "Membrane topology of the pBR322 tetracycline resistance protein. TetA-PhoA gene fusions and implications for the mechanism of TetA membrane insertion". The Journal of Biological Chemistry. 267 (25): 17809–19. doi:10.1016/S0021-9258(19)37116-9. PMID 1517220.
Tet Repressor proteins (otherwise known as TetR) are proteins playing an important role in conferring antibiotic resistance to large categories of bacterial...
encoding the ampicillin resistance (AmpR) protein, and the gene tetA encoding the tetracycline resistance (TetR) protein. It contains the origin of replication...
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Disulfiram is a medication used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram...
portion of Tn10, tetA and tetR, confer resistance to the antibiotic tetracycline. This activity of tetR forms the basis of the TetOFF assembly, a widely-used...
September 2023 "TETR.IO - TetrisWiki". tetris.wiki. Archived from the original on 3 September 2022. Retrieved 15 October 2022. "ABOUT - TETR.IO". tetr.io. Archived...
of the TetR family of tetracycline repressors and is a homodimer. Many of its structural features resemble that of other proteins in the TetR family,...
Manuel Martinez Bueno; Antonio J Molina-Henares; et al. (1 June 2005). "The TetR family of transcriptional repressors". Microbiology and Molecular Biology...
signature indels (CSIs) that are uniquely present in this family in the proteins TetR family transcriptional regulator and a hypothetical protein. These CSIs provide...
monosaccharides combines a Greek prefix to indicate the number of carbons (tri-, tetr-, pent-, hex-, etc.) with the suffixes "-ose" for aldoses and "-ulose" for...
The TET enzymes are a family of ten-eleven translocation (TET) methylcytosine dioxygenases. They are instrumental in DNA demethylation. 5-Methylcytosine...
part of a 3 gene operon, whose expression is negatively regulated by CifR, a TetR family repressor. Cif was first discovered by co-culturing P. aeruginosa...
Thor-Delta was a US expendable launch system used to launch the Pioneer E and TETR satellites in 1969 (failed) and HEOS satellite in 1972. It was a member of...
glycosylase to tetR DNA-binding domain. This has been shown to increase mutation rates by over 800 time in regions of the genome containing tetO sites.[page needed]...
artist under the moniker Four Tet, and has performed as part of the duo Kieran Hebden and Steve Reid. To date, Four Tet has released twelve studio albums...
Ṭēth or Tet, is the ninth letter of the Semitic abjads, including Phoenician ṭēt 𐤈, Proto-semitic tē , Hebrew ṭēt ט, Aramaic ṭēṯ 𐡈, Syriac ṭēṯ ܛ, and...
газета Леонид Иванович Губанов — Киносозвездие Леонид Губанов at the kino-tetr.ru Указ Президента Российской Федерации от 23 октября 1998 года № 1300 Указ...
equal temperament, without qualification, generally means 12 TET. In modern times, 12 TET is usually tuned relative to a standard pitch of 440 Hz, called...
PMID 22083395. S2CID 3466672. Wei, J; Tian, Y; Niu, G; Tan, H (January 2014). "GouR, a TetR family transcriptional regulator, coordinates the biosynthesis and export...
coli phage lambda PL (λ PL) promoter with lac repressor (Lacl) and Tet repressor (TetR) operator sequences. Second, to reduce the disparity between the...
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