High Resolution Crystal Structure of Human Complement Component 8[1]
Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).
A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.
Membrane attack complex. Some labels are in Polish.
complement component 8, alpha polypeptide
Identifiers
Symbol
C8A
NCBI gene
731
HGNC
1352
OMIM
120950
RefSeq
NM_000562
UniProt
P07357
Other data
Locus
Chr. 1 p36.2-22.1
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Structures
Swiss-model
Domains
InterPro
complement component 8, beta polypeptide
Identifiers
Symbol
C8B
NCBI gene
732
HGNC
1353
OMIM
1209660
RefSeq
NM_000066
UniProt
P073o58
Other data
Locus
Chr. 1 p36.2-22.1
Search for
Structures
Swiss-model
Domains
InterPro
complement component 8, gamma polypeptide
Identifiers
Symbol
C8G
NCBI gene
733
HGNC
1354
OMIM
120930
RefSeq
NM_000606
UniProt
P07360
Other data
Locus
Chr. 9 q34.3
Search for
Structures
Swiss-model
Domains
InterPro
^PDB: 3OJY; Lovelace LL, Cooper CL, Sodetz JM, Lebioda L (May 2011). "Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement". The Journal of Biological Chemistry. 286 (20): 17585–92. doi:10.1074/jbc.M111.219766. PMC 3093833. PMID 21454577.
attack complex (MAC). A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea. C8 is...
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C5b-6-7 complex. The C5b-6-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-6-7-8 complex. C5b-6-7-8...
since 1953. Throughout eight generations, indicated sequentially as C1 to C8, the Corvette is noted for its performance, distinctive styling, lightweight...
attack pathway, which results in the membrane attack complex (MAC), consisting of C5b, C6, C7, C8, and polymeric C9. MAC is the cytolytic endproduct of...
(16 atoms per conventional unit cell). Claims were made that the so-called C8 structure had been synthesized, having eight-carbon cubes similar to cubane...
and complex wide-field designs such as the X-Cel and Luminos eyepiece lines.[clarification needed] Celestron NexStar 114 telescope Celestron C8 telescope...
in mupirocin are pseudomonic acid B with an additional hydroxyl group at C8, pseudomonic acid C with a double bond between C10 and C11, instead of the...
the six convex regular 4-polytopes. The tesseract is also called an 8-cell, C8, (regular) octachoron, or cubic prism. It is the four-dimensional measure...
card management system "ISO/IEC 7816-2:2007 – Assignment of contacts C4 and C8". iso.org. Archived from the original on 4 March 2016. Retrieved 20 August...
neighbourhood, Villa Lugano is characterised by its numerous public housing complexes built in the late 20th century, such as Barrio General Manuel Savio (commonly...
Proteasome subunit alpha type-3 also known as macropain subunit C8 and proteasome component C8 is a protein that in humans is encoded by the PSMA3 gene. This...
ro/semnarea-programului-de-cooperare-%C3%AEn-domeniul-educa%C8%9Biei-%C3%AEntre-ministerul-educa%C8%9Biei-na%C8%9Bionale-din-0 "Rumunsko". "75 de ani de invatamant...
Leader-Post. Regina, Saskatchewan, Canada. Associated Press. July 14, 1986. p. C8. Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective...
Kawaguchi, Yasuhiro; Nakamoto, Keiichi; Ishida, Toru; Takeuchi, Yoshimi (2009). "C8 Artistic Machining by Means of Multi-tasking Machine(Multi-axis control machining)"...
condition affecting the complement membrane attack complex (MAC). It involves deficiencies of C5, C6, C7, and C8. (While C9 is part of the MAC, and deficiencies...
malonyl-CoA synthetase (ACSF3), which then becomes the final product octanoyl-ACP (C8) via further intermediate steps. Straight-chain fatty acids occur in two types:...
enzymes that are not dependent on it. Vitamin B12 is the most chemically complex of all vitamins, and for humans the only vitamin that must be sourced from...
messenger RNA. GTFs, RNA polymerase, and the mediator (a multi-protein complex) constitute the basic transcriptional apparatus that first bind to the...
cyanide, converting the cobalt(II) salt into a pentacyanocobaltate(II) complex that reacts with carbon monoxide to yield K[Co(CO)4]. Acidification produces...