In materials science (specifically crystallography), cocrystals are "solids that are crystalline, single-phase materials composed of two or more different molecular or ionic compounds generally in a stoichiometric ratio which are neither solvates nor simple salts."[1] A broader definition is that cocrystals "consist of two or more components that form a unique crystalline structure having unique properties." Several subclassifications of cocrystals exist.[2][3]
Cocrystals can encompass many types of compounds, including hydrates, solvates and clathrates, which represent the basic principle of host–guest chemistry. Hundreds of examples of cocrystallization are reported annually.
^Aitipamula, Srinivasulu (2012). "Polymorphs, Salts, and Cocrystals: What's in a Name?". Crystal Growth & Design. 12 (5): 2147–2152. doi:10.1021/cg3002948.
^Tilborg, Anaëlle (2014). "Pharmaceutical salts and cocrystals involving amino acids: A brief structural overview of the state-of-art". European Journal of Medicinal Chemistry. 74: 411–426. doi:10.1016/j.ejmech.2013.11.045. PMID 24487190.
In materials science (specifically crystallography), cocrystals are "solids that are crystalline, single-phase materials composed of two or more different...
that a cocrystal of CL-20 and TNT had twice the stability of CL-20—safe enough to transport, but when heated to 136 °C (277 °F) the cocrystal may separate...
two polymorphs that differ in the conformation of the oxaborole ring. A cocrystal with 4,4'-bipyridine has been prepared and studied by X-ray crystallography...
directors and is a 10% owner of Cocrystal Pharma, Inc., which was formed from a merger of BioZone Pharmaceuticals, Inc. and Cocrystal Discovery Inc. This company...
Matzger, A. J. (2012). "High Power Explosive with Good Sensitivity: A 2:1 Cocrystal of CL-20:HMX". Crystal Growth & Design. 12 (9): 4311. doi:10.1021/cg3010882...
(non-charged) organic molecules the line phase is commonly known as a cocrystal. In metallurgy alloys with a set composition are referred to as intermetallic...
antihistamine (Alfadryl). It is, with 8-chlorotheophylline, a component of cocrystal/salt moxastine teoclate (mephenhydrinate) used as antiemetic (Theadryl;...
Miranda L.; Zaworotko, Michael J. (2016). "Chloral Hydrate Polymorphs and Cocrystal Revisited: Solving Two Pharmaceutical Cold Cases". Crystal Growth & Design...
caffeine, as implied by its name, caffeine citrate in fact consists of cocrystals of the two components. Caffeine citrate is in the xanthine family of medication...
1021/ar400308f. PMID 24617966. Morimoto, M.; Irie, M. (2010). "A Diarylethene Cocrystal that Converts Light into Mechanical Work". Journal of the American Chemical...
forms of APIs (Active Pharmaceutical Ingredients) named as pharmaceutical cocrystals. Supercritical fluid technology offers a new platform that allows a single-step...
"Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution". Proceedings of the National Academy of Sciences...
Miao; Yang, Xiaomei; Lu, Yalin; Zang, Ling (2017). "Donor–acceptor single cocrystal of coronene and perylene diimide: molecular self-assembly and charge-transfer...
spectroscopy; the bond length is re = 1.758981(50) Å. The bond length in a cocrystal with methylchloride is 1.822(2) Å; the lengthening relative to the free...
e PDB gallery 1ej1: COCRYSTAL STRUCTURE OF THE MESSENGER RNA 5' CAP-BINDING PROTEIN (EIF4E) BOUND TO 7-METHYL-GDP 1ej4: COCRYSTAL STRUCTURE OF EIF4E/4E-BP1...
Global Information