In molecular biology, bacterial DNA binding proteins are a family of small, usually basic proteins of about 90 residues that bind DNA and are known as histone-like proteins.[1][2] Since bacterial binding proteins have a diversity of functions, it has been difficult to develop a common function for all of them. They are commonly referred to as histone-like and have many similar traits with the eukaryotic histone proteins. Eukaryotic histones package DNA to help it to fit in the nucleus, and they are known to be the most conserved proteins in nature.[3] Examples include the HU protein in Escherichia coli, a dimer of closely related alpha and beta chains and in other bacteria can be a dimer of identical chains. HU-type proteins have been found in a variety of bacteria (including cyanobacteria) and archaea, and are also encoded in the chloroplast genome of some algae.[4] The integration host factor (IHF), a dimer of closely related chains which is suggested to function in genetic recombination as well as in translational and transcriptional control[5] is found in Enterobacteria and viral proteins including the African swine fever virus protein A104R (or LMW5-AR).[6]
This family is also found in a group of eukaryotes known as dinoflagellates. These dinoflagellate histone-like proteins replace histone in some dinoflagellates and package DNA into a liquid-crystalline state.[7]
^Pettijohn DE (September 1988). "Histone-like proteins and bacterial chromosome structure". The Journal of Biological Chemistry. 263 (26): 12793–6. doi:10.1016/S0021-9258(18)37625-7. PMID 3047111.
^Griffiths, Anthony; Wessler, Susan; Carroll, Sean; Doebly, John. Introduction to Genetic Analysis (10 ed.). New York: W. H. Freeman and Company. pp. 428–429.
^Wang SL, Liu XQ (December 1991). "The plastid genome of Cryptomonas phi encodes an hsp70-like protein, a histone-like protein, and an acyl carrier protein". Proceedings of the National Academy of Sciences of the United States of America. 88 (23): 10783–7. Bibcode:1991PNAS...8810783W. doi:10.1073/pnas.88.23.10783. PMC 53015. PMID 1961745.
^Friedman DI (November 1988). "Integration host factor: a protein for all reasons" (PDF). Cell. 55 (4): 545–54. doi:10.1016/0092-8674(88)90213-9. hdl:2027.42/27063. PMID 2972385. S2CID 8548040.
^Neilan JG, Lu Z, Kutish GF, Sussman MD, Roberts PC, Yozawa T, Rock DL (March 1993). "An African swine fever virus gene with similarity to bacterial DNA binding proteins, bacterial integration host factors, and the Bacillus phage SPO1 transcription factor, TF1". Nucleic Acids Research. 21 (6): 1496. doi:10.1093/nar/21.6.1496. PMC 309344. PMID 8464748.
^Riaz, S; Sui, Z; Niaz, Z; Khan, S; Liu, Y; Liu, H (14 December 2018). "Distinctive Nuclear Features of Dinoflagellates with A Particular Focus on Histone and Histone-Replacement Proteins". Microorganisms. 6 (4): 128. doi:10.3390/microorganisms6040128. PMC 6313786. PMID 30558155.
and 18 Related for: Bacterial DNA binding protein information
molecular biology, bacterialDNAbindingproteins are a family of small, usually basic proteins of about 90 residues that bind DNA and are known as histone-like...
DnaG is a bacterialDNA primase and is encoded by the dnaG gene. The enzyme DnaG, and any other DNA primase, synthesizes short strands of RNA known as...
of zinc fingers with DNA. The binding of zinc finger is found to be distinct from many other DNA-bindingproteins that bind DNA through the 2-fold symmetry...
Bacterial transcription is the process in which a segment of bacterialDNA is copied into a newly synthesized strand of messenger RNA (mRNA) with use of...
which contains multiple binding sites for the initiator proteinDnaA (a highly homologous protein amongst bacterial kingdom). DnaA has four domains with...
with the DnaA boxes to start chromosomal replication. In addition to the DnaA protein, its concentration, binding to DnaA-boxes, and binding of ATP or...
(IHF) is a bacterialDNAbindingprotein complex that facilitates genetic recombination, replication, and transcription by binding to specific DNA sequences...
DNA sequences used in the construction of recombinant DNA molecules can originate from any species. For example, plant DNA can be joined to bacterial...
proteins that form a DNA gyrase that is employed in phage DNA replication during infection of the E. coli bacterial host. The phage gene 52 protein shares...
A DNA clamp, also known as a sliding clamp, is a protein complex that serves as a processivity-promoting factor in DNA replication. As a critical component...
the phage protein Int and the bacterialprotein IHF (integration host factor). Both Int and IHF bind to attP and form an intasome, a DNA-protein-complex...
addition to protein G, other immunoglobulin-bindingbacterialproteins such as protein A, protein A/G and protein L are all commonly used to purify, immobilize...
IHF may stand for: Integration host factor, a bacterialDNA-bindingprotein International Handball Federation, international governing body of handball...
the DNA, and (2) a protein which binds to this sequence to physically stop DNA replication. In various bacterial species, this is named the DNA replication...
Replication protein A (RPA) is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. In vitro, RPA shows a much higher affinity...
clusters to ssDNA to form a nucleoprotein filament. The protein has more than one DNAbinding site, and thus can hold a single strand and double strand...
distinct group of DNA-bindingproteins is the DNA-bindingproteins that specifically bind single-stranded DNA. In humans, replication protein A is the best-understood...
addition to protein A, other immunoglobulin-bindingbacterialproteins such as protein G, protein A/G and protein L are all commonly used to purify, immobilize...
Global Information