Removal of autoreactive B and T cells before they become immunocompetent
In immunology, clonal deletion is the process of removing T and B lymphocytes from the immune system repertoire.[1][2] The process of clonal deletion helps prevent recognition and destruction of the self host cells, making it a type of negative selection. Ultimately, clonal deletion plays a role in central tolerance.[3] Clonal deletion can help protect individuals against autoimmunity, which is when an organism produces and immune response on its own cells. It is one of many methods used by the body in immune tolerance.
^Russell, John H. (1998-01-01), Delves, Peter J. (ed.), "Clonal Deletion", Encyclopedia of Immunology (Second Edition), Oxford: Elsevier, pp. 569–573, ISBN 978-0-12-226765-9, retrieved 2024-04-23
^Rose N. R. (2015). Molecular mimicry and clonal deletion: A fresh look. Journal of theoretical biology, 375, 71–76. https://doi.org/10.1016/j.jtbi.2014.08.034
^Jenni., Punt; A., Stranford, Sharon; P., Jones, Patricia; Janis., Kuby (2013-01-01). Kuby immunology. W.H. Freeman. ISBN 9781429219198. OCLC 820117219.
immunology, clonaldeletion is the process of removing T and B lymphocytes from the immune system repertoire. The process of clonaldeletion helps prevent...
pre-existing clones of lymphocytes, which expand in response to specific antigen (process called "clonal selection"). This specific clonal army then combats...
food antigens and allergens. Self reactive cells are subject to clonaldeletion or clonal diversion. Both processes of peripheral tolerance control the...
anemone, also called clonal anemone Vegetative cloning, a form of asexual reproduction in plants Clonal reproduction Clonaldeletion, a process by which...
bind a self peptide, then they are signaled to apoptose (process of clonaldeletion). The thymic epithelial cells display self antigen to the T cells to...
strongly to self-antigen, then the B cell undergoes one of four fates: clonaldeletion, receptor editing, anergy, or ignorance (B cell ignores signal and...
ability to deal with these autoreactive clones via mediation of the processes of central tolerance, namely clonaldeletion or T regulatory cells selection, respectively...
abrogated by thymus-dependent dextran conjugates: evidence against clonaldeletion as the mechanism of tolerance induction". Scandinavian Journal of Immunology...
tolerance. Just as in T cells, clonaldeletion and clonal anergy can physically eliminate autoreactive B cell clones. Receptor editing is another mechanism...
Sprent, Jonathan, and Susan R. Webb. "Intrathymic and extrathymic clonaldeletion of T cells." Current opinion in immunology 7.2 (1995): 196-205. Crotty...
is allowed to proliferate or is killed off through a process called clonaldeletion. Normally, the immune system is able to recognize and ignore the body's...
Three hypotheses have gained widespread attention among immunologists: Clonaldeletion theory, proposed by Burnet, according to which self-reactive lymphoid...
In mice models, most mother's fetal-specific CD8+ T cells undergo clonaldeletion and express low levels of chemokine receptors and ligands – this prevents...
were the first to propose the deletion of self-reactive lymphocytes to establish tolerance, now termed clonaldeletion. Burnet and Medawar were ultimately...
processes of central tolerance take place in thymic medulla, namely clonaldeletion (recessive tolerance) and T Regulatory cells selection (dominant tolerance)...
activity is selective but is not T-cell receptor mediated. Both clonal anergy and clonaldeletion have been shown to operate in vetoed T cells. The veto cell...
Whitacre CC, Liu Y, Bai XF (July 2008). "Autoreactive T cells escape clonaldeletion in the thymus by a CD24-dependent pathway". Journal of Immunology....
anti-CD4 monoclonal antibodies, demonstrating that neither thymus nor clonaldeletion is necessary to induce tolerance. In 1989 was successfully induced...
dendritic cell with T cell receptors on the T cell. This can induce T cell clonaldeletion, T cell anergy or the proliferation of regulatory T cells (Tregs)....
maintenance of central and peripheral tolerance through induction of T cell clonaldeletion, T cell anergy and generation and activation of regulatory T (Treg)...
Most T cells are, in time, eliminated in the thymus by a process of clonaldeletion. However, some of them escape this process and are then "mopped up"...
mice: deletion of nonmatare CD4+8+ thymoqttes. Nature 333, 742-746 (1988); Swat, W., Ignatowicz, L., von Boehmer, H. and Kisielow, P.: Clonaldeletion of...
yeast deletion project, formally the Saccharomyces Genome Deletion Project, is a project to create data for a near-complete collection of gene-deletion mutants...
message without the supposedly deleted text, while that text, and the deletion codes, would be visible to the recipient. This sequence is still used humorously...
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