Chromosome jumping is a tool of molecular biology that is used in the physical mapping of genomes. It is related to several other tools used for the same purpose, including chromosome walking.
Chromosome jumping is used to bypass regions difficult to clone, such as those containing repetitive DNA, that cannot be easily mapped by chromosome walking, and is useful in moving along a chromosome rapidly in search of a particular gene. Unlike chromosome walking, chromosome jumping is able to start on one point of the chromosome in order to traverse potential distant point of the same chromosome without cloning the intervening sequences.[1] The ends of a large DNA fragment is the target cloning section of the chromosome jumping while the middle section gets removed by sequences of chemical manipulations prior to the cloning step. [2]
^Drumm ML (May 2001). "Construction of chromosome jumping and linking libraries in E. coli". Current Protocols in Human Genetics. 1 (1): 5.4.1–5.4.17. doi:10.1002/0471142905.hg0504s01. PMID 18428292. S2CID 30214478.
^Poustka A, Lehrach H (January 1986). "Jumping libraries and linking libraries: the next generation of molecular tools in mammalian genetics". Trends in Genetics. 2: 174–179. doi:10.1016/0168-9525(86)90219-2. ISSN 0168-9525.
and 23 Related for: Chromosome jumping information
Chromosomejumping is a tool of molecular biology that is used in the physical mapping of genomes. It is related to several other tools used for the same...
Jumping libraries or junction-fragment libraries are collections of genomic DNA fragments generated by chromosomejumping. These libraries allow the analysis...
The Y chromosome is one of two sex chromosomes in therian mammals and other organisms. Along with the X chromosome, it is part of the XY sex-determination...
which uses random primers instead of specifically chosen ones. ChromosomejumpingChromosome landing Shotgun sequencing – an alternative method, using random...
gene-linkage studies were able to map the mutation to chromosome 7. Chromosome walking and chromosomejumping techniques were then used to identify and sequence...
named chromosomejumping, to emphasize the contrast with an older and much more time-consuming method of copying DNA fragments called chromosome walking...
biology/cytology (a subdivision of human anatomy), that is concerned with how the chromosomes relate to cell behaviour, particularly to their behaviour during mitosis...
researcher. In Weissman's lab, Collins developed the technique known as chromosomejumping. In 1978, Weissman published the complete nucleic acid sequence of...
A transposable element (TE, transposon, or jumping gene) is a nucleic acid sequence in DNA that can change its position within a genome, sometimes creating...
alteration in transcription. This incorporation of the jumping gene near genes involved in chromosome replication is thought to make the rearrangement in...
set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual...
within the FMR1 (fragile X messenger ribonucleoprotein 1) gene on the X chromosome. This results in silencing (methylation) of this part of the gene and...
section of genetic material is copied from one chromosome to another, without the donating chromosome being changed) (see SDSA – Synthesis Dependent Strand...
protein (WT33) is a protein that in humans is encoded by the WT1 gene on chromosome 11p. This gene encodes a transcription factor that contains four zinc...
kinds of sperm, one with a large chromosome and one with a small chromosome. When the sperm with the large chromosome fertilized eggs, they produced female...
mechanism by which chromosomes exchange information. She produced the first genetic map for maize, linking regions of the chromosome to physical traits...
be referred to with much longer chemical names. For example, the wheat chromosome 3B contains almost 1 billion base pairs, so the sequence of one of its...
eyes among all ants, are known for their ability to jump, and have the highest number of chromosomes of any member of the subfamily Formicinae (2n=78)....
maize ear on a stalk Male flowers Mature silk Maize is diploid with 20 chromosomes. 83% of allelic variation within the genome derives from its teosinte...
the library of a genomic format that chromosome walking requires.[citation needed] Yeast artificial chromosome or YAC is a DNA molecule that is developed...
mutation in the SERPINF1 gene on chromosome 17p13.3.: 170 Type VII – OI caused by a mutation in the gene CRTAP on chromosome 3p22.3; clinically similar to...
and Finno-Ugric speaking populations of Northern and Eastern Europe. Y-chromosome SNP haplogroup analysis showed Lithuanians to be genetically closest to...
in the general European population, be they for patrilineal markers (Y-chromosome haplotypes) and for matrilineal markers (mitotypes). Since the middle...
Global Information