Cholinesterase reactivators are drugs that reverse the inhibition of cholinesterase by organophosphates or sulfonates.[1] They are used as antidote for treating organophosphate insecticide and nerve agent poisoning.[2]
^Antonijevic, B.; Stojiljkovic, M. P. (1 March 2007). "Unequal Efficacy of Pyridinium Oximes in Acute Organophosphate Poisoning". Clinical Medicine & Research. 5 (1): 71–82. doi:10.3121/cmr.2007.701. PMC 1855336. PMID 17456837.
and 26 Related for: Cholinesterase reactivator information
Cholinesterasereactivators are drugs that reverse the inhibition of cholinesterase by organophosphates or sulfonates. They are used as antidote for treating...
ability to perform military tasks during exposure. Similarly, cholinesterasereactivators antidotes such as 2-PAM were tested on about 750 subjects. These...
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter...
"Current understanding of the application of pyridinium oximes as cholinesterasereactivators in treatment of organophosphate poisoning". European Journal...
pseudocholinesterase, or plasma (cholin)esterase, is a nonspecific cholinesterase enzyme that hydrolyses many different choline-based esters. In humans...
Rivastigmine (sold under the trade name Exelon among others) is a cholinesterase inhibitor used for the treatment of mild to moderate Alzheimer's disease...
resistant to oxime reactivators, meaning the acetylcholinesterase inhibited by MFPCh can't be reactivated by cholinesterasereactivators. MFPCh also acts...
treatment of choice pralidoxime (Protopam, 2-PAM) can be used as a cholinesterasereactivator in cases of severe poisoning. Less than 48 hours after poisoning...
2015 Jokanović M, Prostran M (2009). "Pyridinium oximes as cholinesterasereactivators. Structure-activity relationship and efficacy in the treatment...
organophosphates, dimethoate is an acetylcholinesterase inhibitor which disables cholinesterase, an enzyme essential for central nervous system function. It acts both...
since the inhibited enzyme ages so rapidly, it can't be reactivated by cholinesterasereactivators. Nerve agent Soman Worek, Franz; Wille, Timo; Koller,...
"Cholinomimetic teratogens. V. The effect of oximes and related cholinesterasereactivators". Teratology. 15 (1): 33–42. doi:10.1002/tera.1420150105. PMID 320703...
oxime. Jokanović M, Prostran M (2009). "Pyridinium oximes as cholinesterasereactivators. Structure-activity relationship and efficacy in the treatment...
irreversible acetylcholinesterase inhibitor and is resistant to cholinesterasereactivators. It was developed in the 1950s and is now believed to be no longer...
such as atropine, considered an antidote; Administration of a cholinesterasereactivator, in the pyridinium oxime family, usually pralidoxime; Administration...
carbamate inhibitor of cholinesterase that does not cross the blood–brain barrier. It carbamylates about 30% of peripheral cholinesterase enzyme, and the carbamylated...
cholinergic agonist (parasympathomimetic). It was the first centrally acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease, and was...
Echothiophate binds irreversibly to cholinesterase. Because of the very slow rate at which echothiophate is hydrolyzed by cholinesterase, its effects can last a week...
functioning of the mammalian nervous system by inhibiting the enzyme cholinesterase. It is an inhibitor of both acetylcholinesterase and butyrylcholinesterase...
acetylhydrolase), also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine...
in the US. Carbaryl is illegal in the EU and Angola. Carbaryl is a cholinesterase inhibitor and is toxic to humans. It is classified as a likely human...
active catalytic site of the cholinesterase enzyme. The resultant phosphoester group is strongly bound to the cholinesterase, and irreversibly deactivates...
its multi-faceted action (non-selective) and rapid inactivation by cholinesterase. However, it is used in the form of eye drops to cause constriction...
and usually improved even with continued use. Donepezil, like other cholinesterase inhibitors, can cause nightmares due to enhanced activation of the visual...
Global Information