Separation of a sample of a chiral compound into its enantiomers
Chiral resolution, or enantiomeric resolution,[1] is a process in stereochemistry for the separation of racemic mixture into their enantiomers.[2] It is an important tool in the production of optically active compounds, including drugs.[3] Another term with the same meaning is optical resolution.
The use of chiral resolution to obtain enantiomerically pure compounds has the disadvantage of necessarily discarding at least half of the starting racemic mixture. Asymmetric synthesis of one of the enantiomers is one means of avoiding this waste.
^Kuhn, Reinhard.; Erni, Fritz.; Bereuter, Thomas.; Haeusler, Johannes. (1992-11-15). "Chiral recognition and enantiomeric resolution based on host-guest complexation with crown ethers in capillary zone electrophoresis". Analytical Chemistry. 64 (22): 2815–2820. doi:10.1021/ac00046a026.
^Smith, Michael B.; March, Jerry (2007), Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th ed.), New York: Wiley-Interscience, p. 173-179, ISBN 978-0-471-72091-1
^William H. Porter (1991). "Resolution of chiral drugs" (PDF). Pure Appl. Chem.63 (8): 1119–1122. doi:10.1351/pac199163081119. S2CID 35860450.
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otherwise be chiral due to a nitrogen stereocenter, nitrogen inversion provides a low energy pathway for racemization, usually making chiralresolution impossible...
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Chemical yield: 1.4%. In addition they isolated (−)-narwardine by chiralresolution from a mixture of racemic narwedine and 0.5 equivalents of (+)-galanthamine...
technique to separate enantiomers of chiral molecules in the pharmaceutical and fine chemical industries (chiralresolution). The exact interplay of the mechanisms...
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