Global InformationRemdesivir information
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| Pronunciation | /rɛmˈdɛsɪvɪər/ rem-DESS-i-veer |
| Trade names | Veklury |
| Other names | GS-5734, RDV |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a620033 |
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| Routes of administration | Intravenous |
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| ECHA InfoCard | 100.302.974 |
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| Formula | C27H35N6O8P |
| Molar mass | 602.585 g·mol−1 |
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Remdesivir, sold under the brand name Veklury,[13][14] is a broad-spectrum antiviral medication developed by the biopharmaceutical company Gilead Sciences.[15] It is administered via injection into a vein.[16][17] During the COVID‑19 pandemic, remdesivir was approved or authorized for emergency use to treat COVID‑19 in numerous countries.[18]
Remdesivir was originally developed to treat hepatitis C,[19] and was subsequently investigated for Ebola virus disease and Marburg virus infections[20] before being studied as a post-infection treatment for COVID‑19.[21]
Remdesivir is a prodrug that is intended to allow intracellular delivery of GS-441524 monophosphate and subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analogue inhibitor of viral RNA polymerase.[22]
The most common side effect in healthy volunteers is raised blood levels of liver enzymes.[13] The most common side effect in people with COVID‑19 is nausea.[13] Side effects may include liver inflammation and an infusion-related reaction with nausea, low blood pressure, and sweating.[23]
The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.[24]
- ^ a b "Veklury Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). 13 July 2020. Archived from the original on 13 August 2020. Retrieved 16 August 2020.
- ^ a b "AusPAR: Remdesivir". Therapeutic Goods Administration (TGA). 10 May 2022. Archived from the original on 10 May 2022. Retrieved 10 May 2022.
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
- ^ "Veklury Powder for Injection Product Information". Therapeutic Goods Administration (TGA). 9 June 2021. Archived from the original on 13 September 2020. Retrieved 16 August 2020.
- ^ "Veklury remdesivir 100 mg powder for injection vial". Therapeutic Goods Administration (TGA). Archived from the original on 23 October 2021. Retrieved 22 October 2021.
- ^ "COVID-19 treatment: Gilead Sciences Pty Ltd, remdesivir (Veklury)". Therapeutic Goods Administration (TGA). 10 July 2020. Archived from the original on 21 October 2021. Retrieved 22 October 2021.
- ^ "Veklury Product information". Health Canada. 25 April 2012. Archived from the original on 26 October 2020. Retrieved 22 October 2020.
- ^ "Summary Basis of Decision (SBD) for Veklury". Health Canada. 23 October 2014. Archived from the original on 30 May 2022. Retrieved 29 May 2022.
- ^ "Veklury (remdesivir)". COVID-19 vaccines and treatments portal. 27 July 2020. Archived from the original on 1 June 2022. Retrieved 31 May 2022.
- ^ "Veklury 100 mg concentrate for solution for infusion – Summary of Product Characteristics (SmPC)". (emc). 6 July 2020. Archived from the original on 24 November 2020. Retrieved 4 October 2020.
- ^ "Veklury 100 mg powder for concentrate for solution for infusion – Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 8 October 2020. Retrieved 4 October 2020.
- ^ "Veklury- remdesivir injection Veklury- remdesivir injection, powder, lyophilized, for solution". DailyMed. 20 June 2023. Archived from the original on 14 July 2023. Retrieved 14 July 2023.
- ^ a b c d "Veklury EPAR". European Medicines Agency (EMA). 23 June 2020. Archived from the original on 18 March 2021. Retrieved 8 August 2022. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ "Gilead Announces Approval of Veklury (remdesivir) in Japan for Patients With Severe COVID-19" (Press release). Gilead Sciences. 7 May 2020. Archived from the original on 26 June 2020. Retrieved 25 June 2020 – via Business Wire.
- ^ Scavone C, Brusco S, Bertini M, Sportiello L, Rafaniello C, Zoccoli A, et al. (April 2020). "Current pharmacological treatments for COVID-19: What's next?". British Journal of Pharmacology. 177 (21): 4813–4824. doi:10.1111/bph.15072. eISSN 1476-5381. PMC 7264618. PMID 32329520.
- ^ "Remdesivir". Drugs.com. 20 April 2020. Archived from the original on 16 April 2020. Retrieved 30 April 2020.
- ^ Mehta N, Mazer-Amirshahi M, Alkindi N, Pourmand A (July 2020). "Pharmacotherapy in COVID-19; A narrative review for emergency providers". The American Journal of Emergency Medicine. 38 (7): 1488–1493. doi:10.1016/j.ajem.2020.04.035. eISSN 0735-6757. PMC 7158837. PMID 32336586.
- ^ "U.S. Food and Drug Administration Approves Gilead's Antiviral Veklury (remdesivir) for Treatment of COVID-19" (Press release). Gilead Sciences, Inc. 22 October 2020. Archived from the original on 23 October 2020. Retrieved 23 October 2020.
- ^ Stephens B (18 April 2020). "The Story of Remdesivir". The New York Times. p. A23. Archived from the original on 22 May 2020. Retrieved 11 May 2020.
- ^ Warren TK, Jordan R, Lo MK, Ray AS, Mackman RL, Soloveva V, et al. (March 2016). "Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys". Nature. 531 (7594): 381–5. Bibcode:2016Natur.531..381W. doi:10.1038/nature17180. PMC 5551389. PMID 26934220.
- ^ Kupferschmidt K, Cohen J (22 March 2020). "WHO launches global megatrial of the four most promising coronavirus treatments". Science Magazine. doi:10.1126/science.abb8497. S2CID 216325781. Archived from the original on 14 September 2020. Retrieved 27 March 2020.
- ^ Yan VC, Muller FL (14 May 2020). "Gilead should ditch remdesivir and focus on its simpler and safer ancestor". Stat. Archived from the original on 12 June 2021. Retrieved 5 July 2020.
- ^ "FDA EUA Remdesivir Fact Sheet for Health Care Providers" (PDF). U.S. Food and Drug Administration (FDA). January 2022. Archived from the original on 24 January 2022. Retrieved 23 January 2022.
This article incorporates text from this source, which is in the public domain.
- ^ "New Drug Therapy Approvals 2020". U.S. Food and Drug Administration (FDA). 31 December 2020. Archived from the original on 18 January 2021. Retrieved 17 January 2021. This article incorporates text from this source, which is in the public domain.
