Cerebellar cognitive affective syndrome information
Cognitive and affective symptoms of cerebellum damage
Medical condition
Cerebellar cognitive affective syndrome
Other names
Schmahmann's syndrome
Specialty
Neurology
Cerebellar cognitive affective syndrome (CCAS), also called Schmahmann's syndrome[1] is a condition that follows from lesions (damage) to the cerebellum of the brain. It refers to a constellation of deficits in the cognitive domains of executive function, spatial cognition, language, and affect resulting from damage to the cerebellum.[2][3][4][5][6] Impairments of executive function include problems with planning, set-shifting, abstract reasoning, verbal fluency, and working memory, and there is often perseveration, distractibility and inattention. Language problems include dysprosodia, agrammatism and mild anomia. Deficits in spatial cognition produce visual–spatial disorganization and impaired visual–spatial memory. Personality changes manifest as blunting of affect or disinhibited and inappropriate behavior. These cognitive impairments result in an overall lowering of intellectual function.[2][4] CCAS challenges the traditional view of the cerebellum being responsible solely for regulation of motor functions. It is now thought that the cerebellum is responsible for monitoring both motor and nonmotor functions. The nonmotor deficits described in CCAS are believed to be caused by dysfunction in cerebellar connections to the cerebral cortex and limbic system.[2][6][7]
^Manto M, Mariën P. Schmahmann’s syndrome – identification of the third cornerstone of clinical ataxiology. Cerebellum and Ataxias 2015, 2:2
^ abcSchmahmann, J. D. & Sherman, J. C. (1998). The cerebellar cognitive affective syndrome. Brain, 121, 561–579.
^Levisohn, L., Cronin-Golomb, A. & Schmahmann, J. D. (2000). Neuropsychological consequences of cerebellar tumor resection in children. Brain, 123, 1041–1050.
^ abSchmahmann, J. D. (2001). The cerebellar cognitive affective syndrome: Clinical correlations of the dysmetria of thought hypothesis. International Review of Psychiatry, 13, 313–322.
^Schmahmann, J. D. (2010). The role of the cerebellum in cognition and emotion: Personal reflections since 1982 on the dysmetria of thought hypothesis, and its historical evolution from theory to therapy. Neuropsychological Review, 20, 236–260.
^ abWolf, U., Rapoport, M. J., & Schweizer, T. A. (2009). Evaluating the affective component of the cerebellar cognitive affective syndrome. Journal of Neuropsychiatry and Clinical Neurosciences, 21, 245–253.
^Schmahmann, J. (1991). An emerging concept. The cerebellar contribution to higher function. Archives of Neurology, 48, 1178–1187.
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