Cartwheel cells are neurons of the dorsal cochlear nucleus (DCN) where they greatly outnumber the other inhibitory interneurons of the DCN. Their somas lie on the superficial side of the pyramidal layer of the DCN, and their dendrites receive input from the parallel fibres of the granule cell layer. Their axons do not extend beyond the dorsal cochlear nucleus but synapse with other cartwheel cells and pyramidal cells within the DCN releasing GABA and glycine onto their targets.
Cartwheel cells have similar spiking patterns to Purkinje cells, firing complex spike bursts as well as simple spikes. They are also seen to share other features common to the cerebellar Purkinje cells.[1] Other data supports the structural and functional similarity found between the cartwheel and the Purkinje neuron.[2] Cartwheel cells are shown to have a high density of spines on their dendrites, their axons are myelinated, they are of spherical cell shape and of medium size.[3] The primary targets of the cartwheel cells are the large efferent pyramidal neurons of the DCN, found in layer two. Data retrieved has shown that this targeting of the pyramidal cells modulates their activity and therefore plays a key role in the shaping of the overall output of the superficial layers of the dorsal cochlear nucleus.[4]
^Mugnaini, E; Morgan, JI (Dec 1987). "The neuropeptide cerebellin is a marker for two similar neuronal circuits in rat brain". Proceedings of the National Academy of Sciences of the United States of America. 84 (23): 8692–6. Bibcode:1987PNAS...84.8692M. doi:10.1073/pnas.84.23.8692. PMC 299612. PMID 3317418.
^Mugnaini, E; Berrebi, AS; Dahl, AL; Morgan, JI (Dec 1987). "The polypeptide PEP-19 is a marker for Purkinje neurons in cerebellar cortex and cartwheel neurons in the dorsal cochlear nucleus". Archives Italiennes de Biologie. 126 (1): 41–67. PMID 3449006.
^"Home". neurolex.org.
^Berrebi, AS; Mugnaini, E (1991). "Distribution and targets of the cartwheel cell axon in the dorsal cochlear nucleus of the guinea pig". Anatomy and Embryology. 183 (5): 427–54. doi:10.1007/BF00186433. PMID 1862946. S2CID 22783529.
Cartwheelcells are neurons of the dorsal cochlear nucleus (DCN) where they greatly outnumber the other inhibitory interneurons of the DCN. Their somas...
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adult human body is estimated to contain about 30 trillion (3×1013) human cells, with the number varying between 20 to 40 trillion depending on factors...
cytoplasm and an eccentric nucleus with heterochromatin in a characteristic cartwheel or clock face arrangement. Their cytoplasm also contains a pale zone that...
arrangements appear to have center points that radiate cells or connective tissue outward. Cartwheel patterns may be irregular and, at lower magnification...
superficial layer contains a set of GABAergic neurons called cartwheelcells that resemble Purkinje cells anatomically and chemically—they receive parallel fiber...
nine-triplet microtubule assembled in a cartwheel structure, and contains centrin, cenexin and tektin. In many cell types, the centrosome is replaced by...
set of small granule cells in the cochlear nucleus. There are also a great number of neighbouring cartwheelcells. The granule cells in turn are the target...
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malignant cutaneous soft-tissue sarcoma. DFSP develops in the connective tissue cells in the middle layer of the skin (dermis). Estimates of the overall occurrence...
Whorled: Multiple concentric objects, or spiral-shaped Cartwheel pattern: Center points that radiate cells or connective tissue outward Major nuclear patterns...
Centriole-Like. Typical centrioles form via a step by step process in which a cartwheel forms, then develops to become a procentriole, and further matures into...
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example, when one moves the head to touch the shoulders, or when doing a cartwheel (roll axis). It is directed superiorly and posteriorly, as per its nomenclature...
centrioles apposed end-to end, which are connected by a continuation of their cartwheel structures. Wikispecies has information related to Phaeoceros laevis....
sagittal plane (as when nodding), and in the frontal plane, as when cartwheeling. Both anterior and posterior canals are oriented at approximately 45°...
daughter Lyly to deliver Gracie's meat purchase to George, and she does a cartwheel before leaving. Because of something Harry von Zell said, Gracie believes...
intermediate between severed mother and daughter centrioles into a pair of cartwheel protein complexes onto which procentrioles assemble. Centrosome maturation...
August 24, 2017. "Climber dies after fall on Mount Hood; witness saw him 'cartwheeling'". USA Today. Retrieved February 18, 2018. "Climber had reached summit...
phosphorylates the centriole protein Ana2/STIL to enable it to bind the "cartwheel protein" Sas6 and thus initiate procentriole formation, the first step...
lumber and plywood for light construction purposes. It is also used for cartwheels, wood carving and musical instruments. The flower is used as a honey source...
as Carparachne aureoflava from the Namib Desert, which uses passive cartwheeling as a form of locomotion. The flic-flac spider can reach speeds of up...