oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
heme binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
metal ion binding
monooxygenase activity
estrogen 16-alpha-hydroxylase activity
Cellular component
organelle membrane
endoplasmic reticulum membrane
intracellular membrane-bounded organelle
endoplasmic reticulum
membrane
Biological process
xenobiotic metabolic process
alkaloid catabolic process
oxidative demethylation
lipid hydroxylation
steroid metabolic process
estrogen metabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1577
13114
Ensembl
ENSG00000106258
ENSMUSG00000038656
UniProt
P20815
Q64481
RefSeq (mRNA)
NM_000777 NM_001190484 NM_001291829 NM_001291830
NM_007820
RefSeq (protein)
NP_000768 NP_001177413 NP_001278758 NP_001278759
NP_031846
Location (UCSC)
Chr 7: 99.65 – 99.68 Mb
Chr 5: 145.37 – 145.41 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cytochrome P450 3A5 is a protein that in humans is encoded by the CYP3A5 gene.
^ abcGRCh38: Ensembl release 89: ENSG00000106258 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000038656 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
encoded by the CYP3A5 gene. CYP3A5 encodes a member of the cytochrome P450 superfamily of enzymes. Like most of the cytochrome P450, the CYP3A5 is expressed...
metabolism of tacrolimus is CYP3A5. Genetic variations within CYP3A5 that result in changes to the activity of the CYP3A5 protein can affect concentrations...
S–ondansetron, whereas CYP3A5 genotype had no impact on S–ondansetron plasma levels, measured 3 hours after drug administration. CYP3A5 was more important...
CYP3A4, CYP3A5 and enzymatic hydrolysis. CES1 oxidizes the tertiary amide carbonyl carbons of edoxabans to carboxylic acid groups. CYP3A4 and CYP3A5 oxidize...
tacrolimus (the increase in the last one being more likely in people with CYP3A5*3 genetic polymorphisms). When more than 20 mg of simvastatin, a lipid-lowering...
licarbazepine are CYP3A4 and CYP3A5 inducers and thus have the potential to decrease the plasma concentration of CYP3A4 and CYP3A5 substrates, including calcium...
steroids and other lipids. The CYP3A cluster consists of four genes: CYP3A4, CYP3A5, CYP3A7, and CYP3A43. The region also contains four pseudogenes: CYP3A51P...
half-life of 59 hours. These pathways are mediated principally by CYP3A4 and CYP3A5. The N-dealykylated metabolite, norchlorcyclizine, bears some structural...
Lemborexant is metabolized primarily by CYP3A4 and to a lesser extent by CYP3A5. The "effective" half-life of lemborexant is 17 to 19 hours while its terminal...
P450 system. It was found to weakly inhibit CYP2B6, CYP2D6, and CYP3A4/CYP3A5, and not to inhibit CYP1A2, CYP2C8, CYP2C9, or CYP2C19. Desloratadine was...
so that they can be removed from the body. It is highly homologous to CYP3A5, another important CYP3A enzyme. While many drugs are deactivated by CYP3A4...
DTBZ is 15 to 22 hours. Liver enzymes involved in inactivation are CYP3A4, CYP3A5 and CYP2D6. The drug is excreted, mostly in form of inactive metabolites...
CYP3A (0–20%) with negligible contributions from the less abundant enzymes CYP3A5, CYP1A1, and CYP3A4. 4-hydroxyclonidine, the main metabolite of clonidine...
Pharmacokinetic data Bioavailability ~50% Protein binding ~87% Metabolism CYP3A4, CYP3A5, CYP1A2 and others Elimination half-life 9–14 h Excretion Bile duct (75%)...
and oxidized in the liver by cytochrome P450 enzymes, including CYP3A4, CYP3A5, CYP2C9, CYP2C19, and CYP2D6. 6β-Hydroxylation and to a lesser extent 16β-hydroxylation...
metabolism. Work with human liver microsomes shows that cannabidiol inhibits CYP3A5 and CYP3A4 to some degree. The number of research projects and scientific...
prolongation. Guanfacine availability is significantly affected by the CYP3A4 and CYP3A5 enzymes. Medications that inhibit or induce those enzymes change the amount...
mosquitos. M1 and M2 also have longer elimination half-lives of about 55 hours. CYP3A5 produces a ninth metabolite. Fermentation of Streptomyces avermitilis yields...
disease. It can cause fetal harm. Osimertinib is metabolized by CYP3A4 and CYP3A5, so substances that strongly inhibit either enzyme, like macrolide antibiotics...
Zonisamide is metabolized mostly by the CYP3A4 isoenzyme, but also CYP3A7 and CYP3A5, to 2-(sulphamoylacetyl)-phenol via reductive cleavage of the 1,2-benzisoxazole...
Bioavailability 11% Metabolism Liver enzymes: major CYP2D6, minor CYP3A4, and minor CYP3A5 Metabolites Dextrorphan 3-methoxymorphinan Elimination half-life 2–4 hours...
well as α-hydroxy bromazolam, were formed by CYP2B6, CYP2C19, CYP3A4, and CYP3A5. Additionally, CYP2C9 was found to catalyse the formation of α-hydroxy bromazolam...
intramuscular 90%+ Protein binding 97% Metabolism Liver: CYP3A3, CYP3A4, CYP3A5 Onset of action Within 5 min (IV), 15 min (IM), 20 min (oral) Elimination...
2007-04-29. Kim KA, Song WK, Park JY (November 2009). "Association of CYP2B6, CYP3A5, and CYP2C19 genetic polymorphisms with sibutramine pharmacokinetics in...
the importance of the CPY3A5*1 and CPY3A5*3 alleles of cytochrome P450 CYP3A5 in hypertensive disease. The paper showed a substantial correlation between...
metabolized by the cytochrome P450 enzymes CYP2A6, CYP2B6, CYP2C9, and CYP3A5. It is also known to be metabolized by the UDP-glucuronosyltransferase enzymes...
enzyme system, including isoenzymes CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, CYP3A5, and CYP3A7. It increases metabolism of many drugs and as a consequence...
Goldenseal has been found to have inhibited cytochrome P450 CYP2D6, CYP3A4 and CYP3A5 activity by approximately 40%, a statistically and clinically significant...
Global Information
