Oxcarbazepine, sold under the brand name Trileptal among others, is a medication used to treat epilepsy.[3][5] For epilepsy it is used for both focal seizures and generalized seizures.[6] It has been used both alone and as add-on therapy in people with bipolar disorder who have had no success with other treatments.[7][5] It is taken by mouth.[3][5]
Common side effects include nausea, vomiting, dizziness, drowsiness, double vision and trouble with walking.[3] Serious side effects may include anaphylaxis, liver problems, pancreatitis, suicide ideation, and an abnormal heart beat.[3][6] While use during pregnancy may harm the baby, use may be less risky than having a seizure.[1][8] Use is not recommended during breastfeeding.[1] In those with an allergy to carbamazepine there is a 25% risk of problems with oxcarbazepine.[3] How it works is not entirely clear.[5]
Oxcarbazepine was patented in 1969 and came into medical use in 1990.[9] It is available as a generic medication.[6] In 2021, it was the 130th most commonly prescribed medication in the United States, with more than 4million prescriptions.[10][11]
^ abcCite error: The named reference Preg2019 was invoked but never defined (see the help page).
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^ abcdefg"Trileptal- oxcarbazepine tablet, film coated Trileptal- oxcarbazepine suspension". DailyMed. Retrieved 9 November 2020.
^"List of nationally authorised medicinal products : Active substance: oxcarbazepine : Procedure no.: PSUSA/00002235/202108" (PDF). Ema.europa.eu. Retrieved 5 June 2022.
^ abcd"Oxcarbazepine Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 13 April 2019.
^ abcBritish national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 319–320. ISBN 9780857113382.
^Mazza M, Di Nicola M, Martinotti G, Taranto C, Pozzi G, Conte G, et al. (April 2007). "Oxcarbazepine in bipolar disorder: a critical review of the literature". Expert Opinion on Pharmacotherapy. 8 (5): 649–656. doi:10.1517/14656566.8.5.649. PMID 17376019. S2CID 25068107.
^Athar F, Ehsan M, Farooq M, Lo KB, Cheema HA, Ahmad S, et al. (May 2022). "Adverse fetal and neonatal outcomes following in-utero exposure to oxcarbazepine: A systematic review and meta-analysis". British Journal of Clinical Pharmacology. 88 (8): 3000–09. doi:10.1111/bcp.15413. PMID 35591806.
^Fischer J, Ganellin CR, eds. (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 532. ISBN 9783527607495.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Oxcarbazepine - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Oxcarbazepine, sold under the brand name Trileptal among others, is a medication used to treat epilepsy. For epilepsy it is used for both focal seizures...
additional therapy for partial-onset seizures epilepsy. Similarly to oxcarbazepine, ESL behaves as a prodrug to (S)-(+)-licarbazepine. As such, their mechanisms...
A popular anticonvulsant that is available in generic formulations. Oxcarbazepine (1990). A derivative of carbamazepine that has similar efficacy and...
fused to an azepine ring. Many pharmaceuticals, such as carbamazepine, oxcarbazepine, and depramine, are based on a dibenzazepine structure. Benzazepine...
efficacy of most hormonal contraception. Carbamazepine, cenobamate, oxcarbazepine, perampanel, phenobarbital, phenytoin, and primidone are examples of...
hyponatremia may result. Some neurological/psychiatric medications (oxcarbazepine, among others) have been found to cause hyponatremia in some patients...
includes medication or surgery. The anticonvulsant carbamazepine or oxcarbazepine is usually the initial treatment, and is effective in about 90% of people...
and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an enantiomer of licarbazepine,...
"Haematidrosis associated with epilepsy in a girl successfully Treated with oxcarbazepine: Case report". Journal of International Medical. 43 (2): 263–69. doi:10...
anti-manic drugs that are not antipsychotics include: Carbamazepine Lithium Oxcarbazepine Valproate Benzodiazepines such as clonazepam or lorazepam may be used...
anticonvulsant used to treat epilepsy and migraine headaches Trileptal (oxcarbazepine) – an anticonvulsant used as a mood stabilizer Trintellix (vortioxetine)...
eliminated all symptoms in some Roemheld syndrome sufferers; Lorazepam, Oxcarbazepine increase GI motility, reduce vagus "noise" (sodium channel blocking...
observed in subjects with schizophrenia after initiation of therapy with oxcarbazepine, potentially reflecting declining allostatic load. In healthy persons...
the brain's glutamate system. For valproic acid, carbamazepine and oxcarbazepine, however, their mood-stabilizing effects may be more related to effects...
anti-seizure medications include carbamazepine, eslicarbazepine acetate, oxcarbazepine, phenobarbital, phenytoin, primidone, and rufinamide. The drugs perampanel...
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