In molecular biology, the CFC domain (Cripto_Frl-1_Cryptic domain) is a protein domain found at the C-terminus of a number of proteins including Cripto (or teratocarcinoma-derived growth factor).[1][2] It is structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2.[1] CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain.[1]
The CFC domain appears to play a crucial role in the tumourigenic activity of Cripto proteins, as it is through the CFC domain that Cripto interferes with the onco-suppressive activity of Activins, either by blocking the Activin receptor ALK4 or by antagonising proteins of the TGF-beta family.[3]
^ abcFoley SF, van Vlijmen HW, Boynton RE, Adkins HB, Cheung AE, Singh J, Sanicola M, Young CN, Wen D (September 2003). "The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis". Eur. J. Biochem. 270 (17): 3610–8. doi:10.1046/j.1432-1033.2003.03749.x. PMID 12919325.
^Calvanese L, Saporito A, Marasco D, D'Auria G, Minchiotti G, Pedone C, Paolillo L, Falcigno L, Ruvo M (November 2006). "Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala". J. Med. Chem. 49 (24): 7054–62. doi:10.1021/jm060772r. PMID 17125258.
^Calvanese L, Saporito A, Oliva R, D' Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L (March 2009). "Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor". J. Pept. Sci. 15 (3): 175–83. doi:10.1002/psc.1091. PMID 19035567.
In molecular biology, the CFCdomain (Cripto_Frl-1_Cryptic domain) is a protein domain found at the C-terminus of a number of proteins including Cripto...
pathway directing vertebrate embryo development. NMR data confirm that the CFCdomain has a C1-C4, C2-C6, C3-C5 disulfide pattern and show that structures are...
substances in Group I of Annex A are: CFCl3 (CFC-11) CF2Cl2 (CFC-12) C2F3Cl3 (CFC-113) C2F4Cl2(CFC-114) C2F5Cl (CFC-115) The provisions of the Protocol include...
The Combined Federal Campaign (CFC) is the workplace giving program of the federal government of the United States. The program is authorized by executive...
CFML also includes many other constructs including ColdFusion Components (CFCs), CFML's version of objects, that allow separating business logic from presentation...
and announcing that it would phase out CFC production. The company further called for worldwide controls on CFC production and for additional countries...
inhaled form, cromolyn sodium inhalation aerosol, due to issues involving CFC-free propellant. As stocks are depleted, this inhaler preparation will no...
associative memories after contextual fear conditioning (CFC). Duke et al. found that 24 hours after CFC in rats, in hippocampus neurons, 2,097 genes (9.17%...
corporation" (CFC), which means that more than 50% of the foreign corporation is owned by U.S. shareholders. Generally, foreign direct investment in CFC's are not...
convertases and forms a complex that facilitates the processing of Nodal. EGF-CFC proteins are membrane bound extracellular factors that serve as essential...
June to August is the summer season. It is Dfc bordering on Cfb, Dfb and Cfc in the Koppen classification. The University of Alaska Anchorage has a 50-acre...
preceding sentences incorporates text from a publication now in the public domain: Robinson, Paschal (1908). "Order of Friars Minor Conventuals". In Herbermann...
Northern Ireland and most of Scotland, experience a subpolar oceanic climate (Cfc). Higher elevations in Scotland experience a continental subarctic climate...
of August 2023. The terrain is rugged, and the subpolar oceanic climate (Cfc) is windy, wet, cloudy, and cool. Despite the northerly climate, the temperatures...
(PFC), lance corporal (LCP), corporal (CPL), and corporal (first class) (CFC), if they perform well. Specialists serve as the junior commanders in the...
biggest impact on total forcing, while methane and chlorofluorocarbons (CFCs) play smaller roles as time goes on. The five major greenhouse gases account...
financial and technology domains. This included the creation of two CCP bodies for overseeing finance; the Central Financial Commission (CFC), as well as the...
Configuration Space Address (0xCF8) I/O port and Configuration Space Data (0xCFC) I/O port. The value written to the Configuration Space Address I/O port...
January It has a Köppen Climate Classification of Subpolar oceanic climate (Cfc) with most of the island classified as Tundra (ET). Iceland has extensive...
major scavenger of stratospheric ozone, with an impact comparable to that of CFCs. About 40% of human-caused emissions are from agriculture. Nitrogen is added...
team would be pretty busy up there.. working for General Brooks [ComUSFK/CFC/UNC] and 3rd Fleet would be available to provide that command element to...
This article incorporates text from this source, which is in the public domain. Walsh, James Joseph (1919). History of Medicine in New York: Three Centuries...
62 mi). ILAS-2 maps the vertical distribution of O3, NO2, HNO3, H2O, CFC-11, CFC-12, CH4, N2O, and ClONO2, as well as the distribution of temperature...
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