ACADL information

ACADL
Identifiers
Aliases	ACADL, acyl-CoA dehydrogenase, long chain, ACAD4, LCAD, acyl-CoA dehydrogenase long chain
External IDs	OMIM: 609576; MGI: 87866; HomoloGene: 37498; GeneCards: ACADL; OMA:ACADL - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	210,225,447 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	66,902,436 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; popliteal artery; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; tibial nerve; ; ascending aorta; ; Achilles tendon; ; left coronary artery; ; right coronary artery; ; right lobe of liver;
	Top expressed in
	right ventricle; ; myocardium of ventricle; ; cardiac muscles; ; digastric muscle; ; intercostal muscle; ; sternocleidomastoid muscle; ; brown adipose tissue; ; thoracic diaphragm; ; atrioventricular valve; ; atrium;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors; acyl-CoA dehydrogenase activity; long-chain-acyl-CoA dehydrogenase activity; oxidoreductase activity; fatty-acyl-CoA binding; palmitoyl-CoA oxidase activity; flavin adenine dinucleotide binding;
Cellular component	mitochondrial membranes; mitochondrial matrix; mitochondrion;
Biological process	cellular lipid catabolic process; negative regulation of fatty acid biosynthetic process; lipid metabolism; negative regulation of fatty acid oxidation; fatty acid metabolic process; regulation of cholesterol metabolic process; fatty acid beta-oxidation; temperature homeostasis; protein homotetramerization; carnitine catabolic process; carnitine metabolic process, CoA-linked; fatty acid beta-oxidation using acyl-CoA dehydrogenase; long-chain fatty acid catabolic process; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	33
	11363
	ENSG00000115361
	ENSMUSG00000026003
	P28330
	P51174
	NM_001608
	NM_007381
	NP_001599
	NP_031407
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-CoA dehydrogenase, long chain is a protein that in humans is encoded by the ACADL gene.^[5]

ACADL is a gene that encodes LCAD - acyl-CoA dehydrogenase, long chain - which is a member of the acyl-CoA dehydrogenase family. The acyl-CoA dehydrogenase family is primarily responsible for beta-oxidation of fatty acids within the mitochondria. LCAD dysfunction is associated with lowered fatty acid oxidation capacity and decreased heat generation. As a result, LCAD deficiency has been correlated with increased cardiac hypertrophy, pulmonary disease, and overall insulin resistance.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115361 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026003 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Acyl-CoA dehydrogenase, long chain".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115361 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026003 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Acyl-CoA dehydrogenase, long chain".

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