acyltransferase activity, transferring groups other than amino-acyl groups
metal ion binding
catalytic activity
enzyme binding
acyltransferase activity
carbon-carbon lyase activity
ligase activity, forming carbon-carbon bonds
acetyl-CoA C-acetyltransferase activity
acetyl-CoA C-acyltransferase activity
C-acetyltransferase activity
Cellular component
mitochondrial matrix
mitochondrial inner membrane
extracellular exosome
mitochondrion
Biological process
response to organic cyclic compound
branched-chain amino acid catabolic process
metanephric proximal convoluted tubule development
ketone body biosynthetic process
brain development
response to starvation
response to hormone
liver development
adipose tissue development
metabolism
protein homooligomerization
acetyl-CoA catabolic process
coenzyme A metabolic process
fatty acid beta-oxidation
coenzyme A biosynthetic process
acetyl-CoA biosynthetic process
ketone body catabolic process
isoleucine catabolic process
propionyl-CoA biosynthetic process
ketone body metabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
38
110446
Ensembl
ENSG00000075239
ENSMUSG00000032047
UniProt
P24752
Q8QZT1
RefSeq (mRNA)
NM_000019
NM_144784
RefSeq (protein)
NP_000010
NP_659033
Location (UCSC)
Chr 11: 108.12 – 108.15 Mb
Chr 9: 53.49 – 53.52 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Acetyl-CoA acetyltransferase, mitochondrial, also known as acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT1 (Acetyl-Coenzyme A acetyltransferase 1) gene.[5]
Acetyl-Coenzyme A acetyltransferase 1 is an acetyl-CoA C-acetyltransferase enzyme.
^ abcGRCh38: Ensembl release 89: ENSG00000075239 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032047 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: acetyl-Coenzyme A acetyltransferase 1".
acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT1 (Acetyl-Coenzyme A acetyltransferase 1) gene. Acetyl-Coenzyme A acetyltransferase...
Human acetyl-coA cholesterol acyltransferase (ACAT1) gene produces a chimeric mRNA through the interchromosomal processing of two discontinuous RNAs transcribed...
acyltransferase, an intracellular protein involved in cholesterol metabolism ACAT1 mRNA, a messenger RNA molecule Acat (deity), a Mayan god of tattooing International...
chromosome 11. For complete list, see the links in the infobox on the right. ACAT1: acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)...
in the genes for ketogenesis (HMGCS2 and HMGCL), for ketolysis (OXCT1, ACAT1). Defects in this pathway can cause varying degrees of inability to cope...
is transported to the endoplasmic reticulum where it is re-esterified by ACAT1 (acyl-CoA: cholesterol acyltransferase 1) and subsequently stored as cytoplasmic...
A:cholesterol acyltransferase 1 (acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional...
compounds to either dispose of toxic metabolites or increase enzyme activity. ACAT1 § Ketothiolase deficiency, another type of OA Ogier de Baulny H, Saudubray...
that inhibits sterol O-acyltransferases (SOAT1 and SOAT2, also known as ACAT1 and ACAT2), enzymes involved in the metabolism and catabolism of cholesterol...
PMC 310951. PMID 11042153. Joyce CW, Shelness GS, Davis MA, et al. (2001). "ACAT1 and ACAT2 Membrane Topology Segregates a Serine Residue Essential for Activity...
(April 2015). "Mitochondrial proteomics with siRNA knockdown to reveal ACAT1 and MDH2 in the development of doxorubicin-resistant uterine cancer". Journal...
2020). "Structural basis for catalysis and substrate specificity of human ACAT1". Nature. 581 (7808): 333–338. Bibcode:2020Natur.581..333Q. doi:10.1038/s41586-020-2290-0...
Global Information
