Chemical alteration of an exogenous substance by or in a biological system
Biotransformation is the biochemical modification of one chemical compound or a mixture of chemical compounds. Biotransformations can be conducted with whole cells, their lysates, or purified enzymes.[1] Increasingly, biotransformations are effected with purified enzymes. Major industries and life-saving technologies depend on biotransformations.[2][3]
^"Biotransformation". IUPAC Goldbook. 2014. doi:10.1351/goldbook.B00667. Retrieved 14 February 2022.
^Andreas Liese; Karsten Seelbach; Christian Wandrey (2006). Liese, Andreas; Seelbach, Karsten; Wandrey, Christian (eds.). Industrial biotransformations (2 ed.). Weinheim: Wiley-VCH. doi:10.1002/3527608184. ISBN 978-3-527-31001-2.
^Kamm, Birgit; Gruber, Patrick R.; Kamm, Michael (2016). "Biorefineries-Industrial Processes and Products". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. pp. 1–38. doi:10.1002/14356007.l04_l01.pub2. ISBN 978-3527306732.
Biotransformation is the biochemical modification of one chemical compound or a mixture of chemical compounds. Biotransformations can be conducted with...
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biochemistry, such as any drug or poison. These pathways are a form of biotransformation present in all major groups of organisms and are considered to be...
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to gamma-valerolactones and hippuric acids which undergo further biotransformation, glucuronidation, sulfation and methylation in the liver. The stereochemical...
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aegypti. DMP administered orally in rats largely undergoes phase I biotransformation to monomethyl phthalate (MMP) via hydrolysis in the liver and intestinal...
sulfate or glucuronic acid. However, there are some differences in biotransformation between certain species. Acetylation, which reduces the solubility...
Inavolisib, or GDC-0077, is an investigational, highly selective inhibitor and degrader of mutant phosphatidylinositol 3-kinase (PI3K) alpha. The PI3K-mediated...
MA, Miah S, Mashio AS, Maki T, Hasegawa H (1 May 2020). "Arsenic biotransformation potential of marine phytoplankton under a salinity gradient". Algal...
Pharmacokinetics: Process of the uptake of drugs by the body, the biotransformation they undergo, the distribution of the drugs and their metabolites...
(17α-methyltestosterone). Metandienone is subject to extensive hepatic biotransformation by a variety of enzymatic pathways. The primary urinary metabolites...
described by Ernst Stadelmann in 1891, who may have observed the biotransformation of infused hemoglobin into bilirubin possibly inspired by Ivan Tarkhanov's...
Caffeic acid is an organic compound with the formula (HO)2C6H3CH=CHCO2H. It is a yellow solid. Structurally, it is classified as a hydroxycinnamic acid...
muscles, and blood. In a study of absorption, distribution, metabolism (biotransformation) and excretion of novaluron, rats received radioactively labeled novaluron...
metabolite is the 3-hydroxylated derivative, with evidence of moderate biotransformation, and the key intermediate is an epoxide. Elimination is not impacted...
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to the relatively rapid removal of the chemical by exhalation or biotransformation. Most people in developed countries have measureable baseline levels...
Melzacka M, Rurak A, Vetulani J (1980). "Preliminary study of the biotransformation of two new drugs, trazodone and etoperidone". Polish Journal of Pharmacology...
undesirable side effects. IUPAC definition Compound that undergoes biotransformation before exhibiting pharmacological effects. Note 1: Modified from ref...
Landiolol (INN) is an ultra short-acting, β1-superselective intravenous adrenergic antagonist, which decreases the heart rate effectively with less negative...
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