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Bioprinting drug delivery is a method of using the three-dimensional printing of biomaterials through an additive manufacturing technique to develop drug delivery vehicles that are biocompatible tissue-specific hydrogels or implantable devices. 3D bioprinting uses printed cells and biological molecules to manufacture tissues, organs, or biological materials in a scaffold-free manner that mimics living human tissue to provide localized and tissue-specific drug delivery, allowing for targeted disease treatments with scalable and complex geometry.
This technique was first developed in the 1950s as patients with incurable diseases demanded higher organ transplantation needs than available donors, and organ transplantations showed limitations with immune responses and organ rejection.[1] Techniques that have been studied include bioprinting hydrogels with various Bio-ink (cell-laden microgel) materials and bioprinting implantable devices that mimic specific tissues or biological functions. A few applications of these printed vehicles include promoting wound healing by delivering antibiotics, anti-inflammatory treatments, or drugs that promote cell differentiation and cell proliferation, providing anticancer treatments directly to tumors, and promoting or inhibiting angiogenesis and vascularization to treat cancer, arterial diseases, heart diseases, and arthritis. In addition, implants can be printed in unique shapes and forms to deliver drugs directly into targeted tissues. A new approach includes adding a fourth dimension to 3D bioprinting, which allows the printed biomaterials to conform, either folding or unfolding, to release drugs in a more controlled manner. Whether 3D or 4D, the application of bioprinting to the development of drug delivery systems allows for biocompatible, biodegradable, universal, and personalized drug vehicles.
^Abasalizadeh, Moghaddam (2020). "Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting". Journal of Biological Engineering. 14: 8. doi:10.1186/s13036-020-0227-7. PMC 7069202. PMID 32190110. S2CID 255987816.
and 27 Related for: Bioprinting drug delivery information
Bioprintingdrugdelivery is a method of using the three-dimensional printing of biomaterials through an additive manufacturing technique to develop drug...
tissue engineering fields. 3D bioprinting covers a broad range of bioprinting techniques and biomaterials. Currently, bioprinting can be used to print tissue...
of polar drugs across epithelial surfaces, and is biocompatible and biodegradable. However, it is not approved by the FDA for drugdelivery. Purified...
use and dynamics of drugs or pharmaceuticals in space environments. Falling in the realm of space medicine, outer space drugdelivery is the practical application...
in the Inactive Ingredient Database (IID). Poloxamer 407 is used in bioprinting applications due to its unique phase-change properties. In a 30% solution...
as extrusion bioprinting, have been researched and subsequently introduced as a means of production. In 2004, the field of bioprinting was drastically...
"Alginate-based hydrogels as drugdelivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting". Journal of Biological...
Microgravity bioprinting is the utilization of 3D bioprinting techniques under microgravity conditions to fabricate highly complex, functional tissue and...
found traction when hydrogels were repurposed for drugdelivery. In 1984, Charles Hull developed bioprinting by converting a Hewlett-Packard inkjet printer...
Mohiuddin M, Zhang LG (July 2018). "3D bioprinting for cardiovascular regeneration and pharmacology". Advanced DrugDelivery Reviews. 132: 252–269. doi:10.1016/j...
4-dimensional printing (4D printing; also known as 4D bioprinting, active origami, or shape-morphing systems) uses the same techniques of 3D printing...
Injectable hydrogels can be used to carry drugs or cells for applications in tissue regeneration or 3D bioprinting. Hydrogels with reversible chemistry are...
achieve organ-targeting drugdelivery and avoid non-specific uptake. Despite the great potential of this nanoparticle-based drugdelivery system, the significant...
nanoparticles into intestinal organoids to form an intestinal Trojan horse for drugdelivery and gene therapy. Subsequent reports showed significant physiological...
Biomolecular Engineering at Rice University. He specialises in biomaterials, drugdelivery, and tissue engineering. Mikos completed undergraduate study in engineering...
drugs, protein, polymers, DNA, or other macromolecules. Some of the applications of clays include drugdelivery, tissue engineering, and bioprinting....
future: recent advances of 3D printing in drugdelivery and healthcare" (PDF). Expert Opinion on DrugDelivery. 16 (10): 1081–1094. doi:10.1080/17425247...
novel polymers for the delivery of siRNA into the body for gene therapy. The group has collaborated with an Indian 3D Bioprinting startup Avay Biosciences...
bioprinting solutions and Aleph Farms that used additive manufacturing to structure turkey cells on the International Space Station. 3D bioprinting has...
supports research related to RNA therapies, genome engineering, and new drugdelivery methods. Within its first ten years, the institute also spun out 29...
separate team reports the development of 'RoboCap', a robotic drugdelivery capsule that enhances drug absorption by tunneling through the mucus layer in the...
the equivalent number of human brain synapses. Researchers present a bioprinting method to produce steak-like cultured meat, composed of three types of...
"To Bioprint or Not to Bioprint". North Carolina Journal of Law and Technology. 17: 123–78. SSRN 2562952. Tran, Jasper (2015). "Patenting Bioprinting"....
extracellular environment. Collagen is also widely used as a bioink for 3D bioprinting and biofabrication of 3D tissue models. The collagen protein is composed...
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