Gradual decrease in cellular function in individual bacteria
Bacterial senescence or bacterial aging refers to the gradual decrease in cellular function in individual bacteria as they increase in age. Indicators of senescence include a decelerated division rate and an increase likelihood of death.[1]
The fundamental cause of aging in bacteria is thought to be the accumulation of deleterious components (aging factors). Asymmetrically dividing bacteria, such as Caulobacter crescentus, show signs of replicative aging.[2] The results for symmetrically dividing bacteria are more nuanced. For example, Escherichia coli, under certain experimental conditions, may exhibit signs of replicative aging caused by subtle asymmetries in its division.[3][4][5]
^Nyström, Thomas (2003-03-25). "Conditional senescence in bacteria: death of the immortals: Bacterial senescence". Molecular Microbiology. 48 (1): 17–23. doi:10.1046/j.1365-2958.2003.03385.x. PMID 12657042. S2CID 35548948.
^Ackermann, M.; Stearns, S. C.; Jenal, U. (2003). "Senescence in a bacterium with asymmetric division". Science. 300 (5627): 1920. doi:10.1126/science.1083532. PMID 12817142. S2CID 34770745.
^Stewart, E. J.; Madden, R.; Paul, G.; Taddei, F. (2005). "Aging and Death in an Organism That Reproduces by Morphologically Symmetric Division". PLOS Biology. 3 (2): e45. doi:10.1371/journal.pbio.0030045. PMC 546039. PMID 15685293.
^Lindner, A. B.; Madden, R.; Demarez, A.; Stewart, E. J.; Taddei, F. (2008). "Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation". Proceedings of the National Academy of Sciences of the United States of America. 105 (8): 3076–3081. Bibcode:2008PNAS..105.3076L. doi:10.1073/pnas.0708931105. PMC 2268587. PMID 18287048.
^Wang, Ping; Lydia Robert; James Pelletier; Wei Lien Dang; Francois Taddei; Andrew Wright; Suckjoon Jun (2010). "Robust Growth of E. coli". Current Biology. 20 (12): 1099–103. doi:10.1016/j.cub.2010.04.045. PMC 2902570. PMID 20537537.
and 23 Related for: Bacterial senescence information
Bacterialsenescence or bacterial aging refers to the gradual decrease in cellular function in individual bacteria as they increase in age. Indicators...
Negligible senescence is a term coined by biogerontologist Caleb Finch to denote organisms that do not exhibit evidence of biological aging (senescence), such...
are bacterial toxins. They are composed of an O-antigen, an outer core, and an inner core all joined by covalent bonds, and are found in the bacterial capsule...
spreading to other areas, including bloodstream infections, liver abscesses, bacterial vaginosis and meningitis. During a pre clinical model, Eggerthella lenta...
increased interbrood intervals. One major factor that affects wild guppies' senescence patterns is the mortality rate caused by predation. Guppies from high-predation...
telomeres with each replication in somatic (body) cells may have a role in senescence and in the prevention of cancer. This is because the telomeres act as...
wide range of Gram-negative bacterial species to transport effectors from the interior (cytoplasm or cytosol) of a bacterial cell across the cellular envelope...
reactions. Genetic disruption of arginase-2 in mouse attenuates the onset of senescence and extends lifespan. Arginase inhibitors have been developed to reduce...
biological aging, known in life sciences as "senescence." Some organisms experience negligible senescence, even exhibiting biological immortality. These...
radicals can damage DNA, lipid, and protein and is able to drive cellular senescence. This is accompanied by a loss in efficiency of DNA damage repair mechanisms...
metabolic environment, extracellular signals, development, learning, senescence and cell death. Cloned genes can also provide tools to examine the biological...
that bears the flowers, flowering, fruit development, seed ripening and senescence. Napa cabbage is an annual plant that reaches the generative period in...
treat patients with coronavirus. Mitochondrial ROS can promote cellular senescence and aging phenotypes in the skin of mice. Ordinarily mitochondrial SOD2...
role in mitochondrial homeostasis to delay both the onset of cellular senescence and the appearance of age-related changes in a 3D human skin model. It...
cycle of mitosis, which eventually blocks cell division and leads to senescence. In budding yeast cells where telomerase has been inactivated through...
Borrelia burgdorferi is a bacterial species of the spirochete class in the genus Borrelia, and is one of the causative agents of Lyme disease in humans...
S2CID 4341684. Engelberg-Kulka H, Amitai S, Kolodkin-Gal I, Hazan R (2006). "Bacterial Programmed Cell Death and Multicellular Behavior in Bacteria". PLOS Genetics...
chemopreventive, perhaps by inducing cellular differentiation and/or cellular senescence in colon epithelial cells. Ursodeoxycholic acid is an epimer of chenodeoxycholic...
intestinal microbiota and PSC and a process referred to as cellular senescence and the senescence-associated secretory phenotype in the pathogenesis of PSC. In...
of three possible states: an irreversible state of dormancy, known as senescence cell suicide, also known as apoptosis or programmed cell death unregulated...
such as seed germination, root growth, flowering, fruit ripening, and senescence. Methyl jasmonate is derived from jasmonic acid and the reaction is catalyzed...
Global Information