Bacterial initiation factor-2 is a bacterial initiation factor.[1]
IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome. IF2, bound to GTP, binds to the 30S P site. After associating with the 30S subunit, fMet-tRNAf binds to the IF2 then IF2 transfers the tRNA into the partial P site. When the 50S subunit joins, it hydrolyzes GTP to GDP and Pi, causing a conformational change in the IF2 that causes IF2 to release and allow the 70S ribosome to form.
Human mitochondria use a nuclear-encoded homolog, MTIF2, for translation initiation.[2]
^Prokaryotic+Initiation+Factor-2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
^D'Souza AR, Minczuk M (July 2018). "Mitochondrial transcription and translation: overview". Essays in Biochemistry. 62 (3): 309–320. doi:10.1042/EBC20170102. PMC 6056719. PMID 30030363.
and 22 Related for: Bacterial initiation factor 2 information
Bacterialinitiationfactor-2 is a bacterialinitiationfactor. IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome. IF2, bound...
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2 release factors are GTPases that enhance the activity of class 1 release factors. It helps the class 1 RF dissociate from the ribosome. Bacterial release...
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located upstream the initiation codon and hybridize to a pyrimidine-rich sequence near the 3' end of the 16S RNA within the 30S bacterial ribosomal subunit...
to DNA following the initiation of transcription by Pol III, unlike bacterial σ factors and most of the basal transcription factors for Pol II transcription...
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