Bacterial glutathione transferases (GSTs; EC 2.5.1.18) are part of a superfamily of enzymes that play a crucial role in cellular detoxification.[2] The primary role of GSTs is to catalyze the conjugation of glutathione (GSH) with the electrophilic centers of a wide variety of molecules. The most commonly known substrates of GSTs are xenobiotic synthetic chemicals. There are also classes of GSTs that utilize glutathione as a cofactor rather than a substrate. Often these GSTs are involved in reduction of reactive oxidative species toxic to the bacterium. Conjugation with glutathione receptors renders toxic substances more soluble, and therefore more readily exocytosed from the cell.[3]
^Rossjohn, Jamie; Polekhina, Galina; Feil, Susanne C; Allocati, Nerino; Masulli, Michele; Ilio, Carmine Di; Parker, Michael W (June 1998). "A mixed disulfide bond in bacterial glutathione transferase: functional and evolutionary implications". Structure. 6 (6): 721–734. doi:10.1016/S0969-2126(98)00074-4. PMID 9655824.
^John D Hayes, Jack U Flanagan, Ian R Jowsey 2005. Glutathione transferases. Annu. Rev. Pharmacol. Toxicol. 45:51-88 doi: 10.1146/annurev.pharmtox.45.120403.095857.
^Liu, Shuchang; Liu, Feng; Jia, Haihong; Yan, Yan; Wang, Hongfang; Guo, Xingqi; Xu, Baohua (28 April 2016). "A glutathione S-transferase gene associated with antioxidant properties isolated from Apis cerana cerana". The Science of Nature. 103 (5–6): 43. Bibcode:2016SciNa.103...43L. doi:10.1007/s00114-016-1362-3. PMID 27126403. S2CID 17260700.
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Bacterialglutathionetransferases (GSTs; EC 2.5.1.18) are part of a superfamily of enzymes that play a crucial role in cellular detoxification. The primary...
cellular glutathione redox potential Glutathione-ascorbate cycle Bacterialglutathionetransferase Thioredoxin, a cysteine-containing small proteins with very...
formation of peptide bonds, referred to as the peptidyl-transferase activity. The bacterial (and archaeal) small subunit contains the 16S rRNA and 21 r-proteins...
electron donor. The glutathione system includes glutathione, glutathione reductase, glutathione peroxidases, and glutathione S-transferases. This system is...
proteins: a nexus of glutathionetransferases and epoxide hydrolases in a metalloenzyme superfamily". Gluthione [sic] Transferases and Gamma-Glutamyl Transpeptidases...
Glutathione S-transferase kappa 1 (GSTK1) is an enzyme that in humans is encoded by the GSTK1 gene which is located on chromosome seven. It belongs to...
C (1986). "Erythrocyte glutathione synthetase deficiency leads not only to glutathione but also to glutathione-S-transferase deficiency". Journal of...
(His) tag, other marker peptides, or a fusion partners such as glutathione S-transferase or maltose-binding protein. Some of these fusion partners may...
(tetrameric). Homotetramers have four identical subunits (such as glutathione S-transferase), and heterotetramers are complexes of different subunits. A tetramer...
AMPylated) to form dephospho-CoA by the enzyme phosphopantetheine adenylyl transferase (COASY; PPAT; CoaD) Finally, dephospho-CoA is phosphorylated to coenzyme...
biosynthesis. Other unique ORFs likely encode products involved with bacterial pathogenesis and at least three of these ORFs show homology to staphylococcal...
binding protein (CBP), maltose binding protein (MBP), Strep-tag and glutathione-S-transferase (GST). The poly(His) tag is a widely used protein tag, which binds...
enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), and peroxidase (POD). As these enzymes are important in...
with glucuronic acid (via the enzyme uridine diphosphate–glucuronyl transferase). In this state, bilirubin is soluble in water and it is called conjugated...
vaccine candidates with good results in experimental animals. A glutathione-S-transferase, a detoxification enzyme in parasites isolated from Setaria cervi...
flavin can reduce the product. Glutathione reductase (GR) catalyzes the reduction of glutathione disulfide (GSSG) to glutathione (GSH). GR requires FAD and...
import receptor, Tom20p. Use of glutathione to reveal specific interactions between Tom20-glutathione S-transferase and mitochondrial precursor proteins"...
glutaredoxin, glutathione peroxidase, bacterial protein disulfide isomerase DsbA, and the N-terminal domain of glutathionetransferase. Thioredoxins have...
ISBN 3-540-28221-1. Packer, Lester (2007). Helmut Sies (ed.). Glutathionetransferases and gamma-glutamyl transpeptidases (Online-Ausg. ed.). Amsterdam...
lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione". Genes Dev. 23 (12): 1387–92. doi:10.1101/gad.1789209. PMC 2701572....