Immunoglobulin-binding protein expressed in group C and G Streptococcal bacteria
Not to be confused with G protein.
GA-like domain
Identifiers
Symbol
?
Pfam
PF17573
InterPro
IPR035152
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Immunoglobulin G-binding protein G
Identifiers
Organism
Streptococcus sp. group G
Symbol
spg
UniProt
P06654
Search for
Structures
Swiss-model
Domains
InterPro
Protein G is an immunoglobulin-binding protein expressed in group C and G streptococcal bacteria much like protein A but with differing binding specificities. It is a ~60-kDA (65 kDA for strain G148 and 58 kDa for strain C40)[1] cell surface protein that has found application in purifying antibodies through its binding to the Fab and Fc region. The native molecule also binds albumin, but because serum albumin is a major contaminant of antibody sources, the albumin binding site has been removed from recombinant forms of protein G. This recombinant protein G, either labeled with a fluorophore or a single-stranded DNA strand, was used as a replacement for secondary antibodies in immunofluorescence and super-resolution imaging.[2]
^Cite error: The named reference Sjobring 1991 was invoked but never defined (see the help page).
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