Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Monocrotaline (MCT) is a pyrrolizidine alkaloid that is present in plants of the Crotalaria genus. These species can synthesise MCT out of amino acids and can cause liver, lung and kidney damage in various organisms. Initial stress factors are released intracellular upon binding of MCT to BMPR2 receptors and elevated MAPK phosphorylation levels are induced, which can cause cancer in Homo sapiens. MCT can be detoxified in rats via oxidation, followed by glutathione-conjugation and hydrolysis.
Monocrotaline (MCT) is a pyrrolizidine alkaloid that is present in plants of the Crotalaria genus. These species can synthesise MCT out of amino acids...
pyrrolizidine alkaloids that are found in Crotalaria plants are monocrotaline and spectabiline. Monocrotaline is most toxic to the pulmonary vasculature and is used...
effects of methylsulfonylmethane on hemodynamics and oxidative stress in monocrotaline-induced pulmonary hypertensive rats". Advances in Pharmacological Sciences...
(June 2018). "Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension". Hypertension. 71 (6): 1156–1163. doi:10...
in differences in toxicity. For example, retronecine-type PAs like monocrotaline are known to be highly hepatotoxic, while other types may exhibit lower...
known to contain pyrrolizidine alkaloids, the most potent of which are monocrotaline, retrorsine and retronecine. Pyrrolizidine alkaloids are found in 3%...
ranges from moderate to severe, as well as damage to other organs. Monocrotaline specifically causes pulmonary arterial hypertension. The longevity of...
Guanidinoethane Sulfonate on Toxicity of the Pyrrolizidine Alkaloid Monocrotaline". Biochemical Pharmacology. 51 (3): 321–329. doi:10.1016/0006-2952(95)02185-X...
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