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Axon terminal information


An axon terminal (A) transmits a signal to neuron B (receiving). Features: 1. Mitochondrion. 2. Synaptic vesicle filled with neurotransmitter molecules. 3. Autoreceptor. 4. Synaptic cleft with neurotransmitter molecules. 5. Postsynaptic receptors activated by neurotransmitters (induction of a postsynaptic potential). 6. Calcium channel. 7. Exocytosis of a vesicle. 8. Recaptured neurotransmitter.

Axon terminals (also called synaptic boutons, presynaptic terminals, or end-feet) are distal terminations of the branches of an axon. An axon, also called a nerve fiber, is a long, slender projection of a nerve cell that conducts electrical impulses called action potentials away from the neuron's cell body to transmit those impulses to other neurons, muscle cells, or glands. Most presynaptic terminals in the central nervous system are formed along the axons (en-passant boutons), not at their ends (terminal boutons).

Functionally, the axon terminal converts an electrical signal into a chemical signal. When an action potential arrives at an axon terminal (A), the neurotransmitter is released and diffuses across the synaptic cleft. If the postsynaptic cell (B) is also a neuron, neurotransmitter receptors generate a small electrical current that changes the postsynaptic potential. If the postsynaptic cell (B) is a muscle cell (neuromuscular junction), it contracts.

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Axon terminal

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Axon terminals (also called synaptic boutons, presynaptic terminals, or end-feet) are distal terminations of the branches of an axon. An axon, also called...

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Axon

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An axon (from Greek ἄξων áxōn, axis) or nerve fiber (or nerve fibre: see spelling differences) is a long, slender projection of a nerve cell, or neuron...

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Synaptic pruning

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as small-scale axon terminal arbor pruning. Axons extend short axon terminal arbors toward neurons within a target area. Certain terminal arbors are pruned...

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Neuron

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region can also receive input from other neurons. The axon terminal is found at the end of the axon farthest from the soma and contains synapses. Synaptic...

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Saltatory conduction

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Dendrite Soma Axon Nucleus Node of Ranvier Axon terminal Schwann cell Myelin sheath In neuroscience, saltatory conduction (from Latin saltus 'leap, jump')...

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Neurotransmission

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which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and react with the...

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Presynaptic inhibition

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inhibitory neurotransmitter, like GABA, acts on GABA receptors on the axon terminal. Or when endocannabinoids act as retrograde messengers by binding to...

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Chemical synapse

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structure and function. The presynaptic axon terminal, or synaptic bouton, is a specialized area within the axon of the presynaptic cell that contains neurotransmitters...

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Quantal neurotransmitter release

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of approximately 20% of an axon terminal's neurotransmitter load. Neurotransmitters are synthesized in the axon terminal where they are stored in vesicles...

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SNARE protein

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the cysteine residues of SNAP-25. As an action potential reaches the axon terminal, depolarization events stimulate the opening of voltage-gated calcium...

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Nervous tissue

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body toward the next neuron. The bulb-like end of the axon, called the axon terminal, is separated from the dendrite of the following neuron by a small gap...

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Depolarization

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depolarization continues from the axon hillock down the axon. The surge of depolarization traveling from the axon hillock to the axon terminal is known as an action...

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Amino acid neurotransmitter

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Neurotransmitters (chemicals) are packaged into vesicles that cluster beneath the axon terminal membrane on the presynaptic side of a synapse in a process called endocytosis...

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Action potential

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the furthest end, the axon loses its insulation and begins to branch into several axon terminals. These presynaptic terminals, or synaptic boutons, are...

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Myelin

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(called action potentials) pass along the axon. The myelinated axon can be likened to an electrical wire (the axon) with insulating material (myelin) around...

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Dopaminergic pathways

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vesicles in axon terminals. Dopamine release from vesicles is triggered by action potential propagation-induced membrane depolarization. The axons of dopamine...

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Antidromic

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axon refers to conduction opposite of the normal (orthodromic) direction. That is, it refers to conduction along the axon away from the axon terminal(s)...

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Muscular system

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neurotransmitter used in skeletal muscle contraction) is released from the axon terminal of the nerve cell when an action potential reaches the microscopic junction...

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Nigrostriatal pathway

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motor loop. Dopaminergic neurons of this pathway release dopamine from axon terminals that synapse onto GABAergic medium spiny neurons (MSNs), also known...

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Cocaine

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reuptake of dopamine from the synaptic cleft into the pre-synaptic axon terminal; the higher dopamine levels in the synaptic cleft increase dopamine...

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Outline of the human nervous system

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Oligodendrocyte (CNS) vs Schwann cell (PNS) Dendrite Soma Axon Nucleus Node of Ranvier Axon terminal Schwann cell Myelin sheath A neuron (also known as a neurone...

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Retina bipolar cell

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fields. The amacrine cells also introduce lateral inhibition to the axon terminal, serving various visual functions including efficient signal transduction...

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Reuptake

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neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it...

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Chandelier cell

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immunostaining. The name comes from the specific shape of their axon arbors, with the terminals forming distinct arrays called "cartridges". The cartridges...

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Neurotransmitter

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Synaptic vesicle Neurotransmitter transporter Receptor Neurotransmitter Axon terminal Synaptic cleft Dendrite A neurotransmitter is a signaling molecule secreted...

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Somatic nervous system

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their axon terminal knobs, which is received by glutamate receptors on the lower motor neurons: from there, acetylcholine is released from the axon terminal...

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Calyx of Held

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the largest in the brain. The related endbulb of Held is also a large axon terminal smaller synapse (15-30 μm in diameter) found in other auditory brainstem...

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Nervous system

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types of cells: neurons and glial cells. Dendrite Soma Axon Nucleus Node of Ranvier Axon terminal Schwann cell Myelin sheath The nervous system is defined...

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