Axon guidance (also called axon pathfinding) is a subfield of neural development concerning the process by which neurons send out axons to reach their correct targets. Axons often follow very precise paths in the nervous system, and how they manage to find their way so accurately is an area of ongoing research.
Axon growth takes place from a region called the growth cone and reaching the axon target is accomplished with relatively few guidance molecules. Growth cone receptors respond to the guidance cues.
Axonguidance (also called axon pathfinding) is a subfield of neural development concerning the process by which neurons send out axons to reach their...
An axon (from Greek ἄξων áxōn, axis) or nerve fiber (or nerve fibre: see spelling differences) is a long, slender projection of a nerve cell, or neuron...
receptors, and cell adhesion molecules that are important for axon growth and guidance. In between filopodia—much like the webbing of the hands—are the...
dramatically increases. Axonguidance is driven by Netrin-1 in the FP region of the spinal cord. During injury cases, specifically cases of axon severance, Wnt...
of a host of processes critical to embryonic development including axonguidance, formation of tissue boundaries, cell migration, and segmentation. Additionally...
known for its expression on the surface of axon growth cones and involvement in signal transduction to steer axon growth away from the source of semaphorin...
not yet been defined; however, netrin is thought to be involved in axonguidance and cell migration during development. Mutations and loss of expression...
of biological processes during embryonic development including the guidance of axon growth cones, formation of tissue boundaries, cell migration, and segmentation...
Netrins are a class of proteins involved in axonguidance. They are named after the Sanskrit word "netr", which means "one who guides". Netrins are genetically...
as a tumour suppressor gene for many years, and is well known as an axonguidance receptor that responds to netrin-1. More recently DCC has been characterized...
Muda M, Dixon JE, Zipursky SL (June 2000). "Drosophila Dscam is an axonguidance receptor exhibiting extraordinary molecular diversity". Cell. 101 (6):...
severe disruption in commissural axon migration; this experiment established the importance of Netrin-1 in guidance decisions. Netrin-1 gradient in Xenopus...
discovered in Drosophila, through a mutant screen for genes involved in axonguidance. The Drosophila roundabout mutant was named after its phenotype, which...
are morphological differences. The mechanisms of pioneer axons and their role in axonguidance is currently being explored. In addition, many studies are...
superfamily) and is both an axonguidance receptor and a cell adhesion receptor, known to be involved in the decision by axons to cross the central nervous...
Roundabout (gene family), the Drosophila melanogaster gene involved in axonguidance in the CNS Robo (film), a 2008 Indian Malayalam film Robo (2010 film)...
proliferation, tumour suppression, cell differentiation, neural development and axonguidance and ageing. Caspase deficiency has been identified as a cause of tumour...
German neuroscientist and physicist known for pioneering studies in axonguidance. Bonhoeffer was born in Frankfurt, Germany. He was the grandson of noted...
SEMA3A) family members. NRP1 plays versatile roles in angiogenesis, axonguidance, cell survival, migration, and invasion.[supplied by OMIM] Neuropilin...
the central nervous system through its involvement in axonguidance. Wnt proteins guide the axons of the spinal cord in an anterior-posterior direction...
the optic chiasm labelled. Cerebrum, inferior view, deep dissection. Guidance of axon crossing and non-crossing during development. Chiasmal syndrome Chiasm...
has also been shown to act as an axonal guidance cue. It has been demonstrated that SHH attracts commissural axons at the ventral midline of the developing...
within individual neurons. These include differentiation, migration, and axonguidance to their initial target areas. These processes are thought of as being...
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