Avian sarcoma leukosis virus (ASLV) is an endogenous retrovirus that infects and can lead to cancer in chickens; experimentally it can infect other species of birds and mammals.[1][2] ASLV replicates in chicken embryo fibroblasts, the cells that contribute to the formation of connective tissues. Different forms of the disease exist, including lymphoblastic, erythroblastic, and osteopetrotic.
Avian sarcoma leukosis virus is characterized by a wide range of tumors, the most common of which are lymphomas. Lymphoid leukosis is the most common form of this disease and with typical presentation of gradual onset, persistent low mortality, and neoplasia of the bursa.[3] The disease is also characterized by an enlarged liver due to infiltration of cancerous lymphoid cells. In addition, other abdominal organs and the bursa of Fabricius are often infected.[4]
^"Leukosis/Sarcoma Group". The Merck Veterinary Manual. 2006. Retrieved 23 June 2007.
^Weiss RA (2006). "The discovery of endogenous retroviruses". Retrovirology. 3: 67. doi:10.1186/1742-4690-3-67. PMC 1617120. PMID 17018135.
^Swayne, David E.; Glisson, John R. (2013). Diseases of Poultry (13th ed.). Wiley. p. 1523. ISBN 978-1-118-71973-2.
^Riddell, C. (May–June 1999). "The current problem with Avian Leukosis J Virus". California Poultry Letter. University of California – Cooperative Extension. Archived from the original on 24 July 2011. Retrieved 12 May 2008.
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