Asparagine synthetase (or aspartate-ammonia ligase) is a chiefly cytoplasmic enzyme that generates asparagine from aspartate.[1] This amidation reaction is similar to that promoted by glutamine synthetase. The enzyme is ubiquitous in its distribution in mammalian organs, but basal expression is relatively low in tissues other than the exocrine pancreas.[2]
Above average presence of asparagine synthetase in certain leukemia strains has been linked to be a significant contributing factor of chemotherapy resistance, particularly to the chemotherapy drug, L-asparaginase.[3]
^Hutson RG, Kitoh T, Moraga Amador DA, Cosic S, Schuster SM, Kilberg MS (May 1997). "Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells". The American Journal of Physiology. 272 (5 Pt 1): C1691-9. doi:10.1152/ajpcell.1997.272.5.C1691. PMID 9176161.
^Balasubramanian MN, Butterworth EA, Kilberg MS (April 2013). "Asparagine synthetase: regulation by cell stress and involvement in tumor biology". American Journal of Physiology. Endocrinology and Metabolism. 304 (8): E789-99. doi:10.1152/ajpendo.00015.2013. PMC 3625782. PMID 23403946.
^Prager MD, Bachynsky N (April 1968). "Asparagine synthetase in asparaginase resistant and susceptible mouse lymphomas". Biochemical and Biophysical Research Communications. 31 (1): 43–7. doi:10.1016/0006-291x(68)90028-4. PMID 4869945.
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Asparaginesynthetase (or aspartate-ammonia ligase) is a chiefly cytoplasmic enzyme that generates asparagine from aspartate. This amidation reaction...
enzyme asparaginesynthetase produces asparagine, AMP, glutamate, and pyrophosphate from aspartate, glutamine, and ATP. Asparaginesynthetase uses ATP...
biosynthesis of asparagine originates with aspartate using a transaminase enzyme. The enzyme asparaginesynthetase produces asparagine, AMP, glutamate...
Friedreich's ataxia. Tandem repeats in the first intron of the Asparaginesynthetase gene are linked to acute lymphoblastic leukaemia. A repeat polymorphism...
glutamate and oxaloacetate. Asparagine is synthesized by an ATP-dependent addition of an amino group onto aspartate; asparaginesynthetase catalyzes the addition...
to a tRNA is known as tRNA charging. Here, the enzyme aminoacyl-tRNA-synthetase catalyzes two reactions. In the first one, it attaches an AMP molecule...
β-lactam synthetase is a 54.5 kDa protein that is encoded by orf3 of the clavulanic acid gene cluster, and shows similarity to asparagine synthase –...
1827 by Auguste-Arthur Plisson and Étienne Ossian Henry by hydrolysis of asparagine, which had been isolated from asparagus juice in 1806. Their original...
the nutrient-sensing response pathway that activates the human asparaginesynthetase gene". The Journal of Biological Chemistry. 277 (27): 24120–24127...
dehydrogenase, succinyl-CoA synthetase, fumarase, and malate dehydrogenase. The urea cycle is facilitated by carbamoyl phosphate synthetase I and ornithine transcarbamylase...
PMID 15890932. Al Sarraj J, Vinson C, Thiel G (2005). "Regulation of asparaginesynthetase gene transcription by the basic region leucine zipper transcription...
Robiquet isolated a compound from asparagus that was subsequently named asparagine, the first amino acid to be discovered. Cystine was discovered in 1810...
blocks of proteins. He did this through recognizing the first of them, asparagine, in 1806, in the industry's adoption of industrial dyes, with the identification...
Amino acids such as lysine, glutamic acid, glutamine, aspartic acid, and asparagine can form isopeptide bonds because they all contain an amino or carboxyl...
"Amino acid deprivation induces the transcription rate of the human asparaginesynthetase gene through a timed program of expression and promoter binding...
symbol Q for glutamine was assigned in alphabetical sequence to N for asparagine, being larger by merely one methylene –CH2– group. Note that P was used...
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