Chemical compound
Arzoxifene (INN Tooltip International Nonproprietary Name ; developmental code name LY-353381 ) is a selective estrogen receptor modulator (SERM) of the benzothiophene group which was never marketed.[1] It is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol. Arzoxifene is a highly effective agent for prevention of mammary cancer induced in the rat by the carcinogen nitrosomethylurea and is significantly more potent than raloxifene in this regard. Arzoxifene is devoid of the uterotrophic effects of tamoxifen, suggesting that, in contrast to tamoxifen, it is unlikely that the clinical use of arzoxifene will increase the risk of developing endometrial carcinoma.
^ Overk CR, Peng KW, Asghodom RT, et al. (2007). "Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene". ChemMedChem . 2 (10): 1520–6. doi:10.1002/cmdc.200700104. PMID 17654759. S2CID 35664796.
Last Update: 2023-08-28T19:33:18Z
Arzoxifene (INNTooltip International Nonproprietary Name; developmental code name LY-353381) is a selective estrogen receptor modulator (SERM) of the benzothiophene...
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Last Update: 2024-05-24T01:32:13Z
27-Hydroxycholesterol Acefluranol Acolbifene Afimoxifene Anordiol Anordrin Arzoxifene Bazedoxifene Brilanestrant Broparestrol Camizestrant Chlorotrianisene...
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Last Update: 2024-05-24T00:52:25Z
27-Hydroxycholesterol Acefluranol Acolbifene Afimoxifene Anordiol Anordrin Arzoxifene Bazedoxifene Brilanestrant Broparestrol Camizestrant Chlorotrianisene...
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Last Update: 2024-05-27T22:02:53Z
27-Hydroxycholesterol Acefluranol Acolbifene Afimoxifene Anordiol Anordrin Arzoxifene Bazedoxifene Brilanestrant Broparestrol Camizestrant Chlorotrianisene...
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Last Update: 2024-06-07T12:18:54Z
8 SERM Raloxifene – 41.2 (7.8–69) 5.34 (0.54–16) 0.188–0.52 20.2 SERM Arzoxifene LY-353,381 ? ? 0.179 ? SERM Lasofoxifene CP-336,156 10.2–166 19.0 0.229...
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Last Update: 2024-06-14T05:22:42Z
27-Hydroxycholesterol Acefluranol Acolbifene Afimoxifene Anordiol Anordrin Arzoxifene Bazedoxifene Brilanestrant Broparestrol Camizestrant Chlorotrianisene...
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Last Update: 2024-06-14T01:34:51Z
27-Hydroxycholesterol Acefluranol Acolbifene Afimoxifene Anordiol Anordrin Arzoxifene Bazedoxifene Brilanestrant Broparestrol Camizestrant Chlorotrianisene...
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Last Update: 2024-05-19T18:14:47Z
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Last Update: 2024-05-27T19:49:23Z
27-Hydroxycholesterol Acefluranol Acolbifene Afimoxifene Anordiol Anordrin Arzoxifene Bazedoxifene Brilanestrant Broparestrol Camizestrant Chlorotrianisene...
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Last Update: 2024-05-18T03:37:50Z
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Last Update: 2024-05-06T01:52:36Z
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Last Update: 2023-12-30T22:35:59Z
27-Hydroxycholesterol Acefluranol Acolbifene Afimoxifene Anordiol Anordrin Arzoxifene Bazedoxifene Brilanestrant Broparestrol Camizestrant Chlorotrianisene...
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Last Update: 2024-02-02T08:12:19Z
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Last Update: 2024-05-27T16:32:15Z
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Last Update: 2024-03-22T02:54:27Z
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Last Update: 2024-06-07T14:41:19Z
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Last Update: 2023-12-09T12:40:36Z
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Last Update: 2024-06-08T21:15:54Z
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Last Update: 2024-06-11T02:47:28Z
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Last Update: 2023-12-23T16:09:59Z
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