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Arylsulfatase A information


ARSA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARSA, MLD, arylsulfatase A, ASA
External IDsOMIM: 607574 MGI: 88077 HomoloGene: 20138 GeneCards: ARSA
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_009713

RefSeq (protein)

NP_033843

Location (UCSC)Chr 22: 50.62 – 50.63 MbChr 15: 89.36 – 89.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arylsulfatase A (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene.[5][6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100299 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022620 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Stein C, Gieselmann V, Kreysing J, Schmidt B, Pohlmann R, Waheed A, Meyer HE, O'Brien JS, von Figura K (January 1989). "Cloning and expression of human arylsulfatase A". J. Biol. Chem. 264 (2): 1252–9. doi:10.1016/S0021-9258(19)85079-2. PMID 2562955.
  6. ^ Matzner U, Herbst E, Hedayati KK, Lüllmann-Rauch R, Wessig C, Schröder S, Eistrup C, Möller C, Fogh J, Gieselmann V (May 2005). "Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy". Hum. Mol. Genet. 14 (9): 1139–52. doi:10.1093/hmg/ddi126. PMID 15772092.

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Arylsulfatase A (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. In humans...

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[citation needed] Arylsulfatase A is activated by saposin B (Sap B), a non-enzymatic proteinaceous cofactor. When the arylsulfatase A enzyme level is normal...

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mucopolysaccharidosis VI (Maroteaux–Lamy syndrome). Arylsulfatase B is among a group of arylsulfatase enzymes present in the lysosomes of the liver, pancreas...

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embryo arylsulfatase EC 3.1.6.1; green algae arylsulfatase EC 3.1.6.1, which plays a role in the mineralization of sulfates; and arylsulfatase EC 3.1...

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Arylsulfatase L is an enzyme that, in humans, is encoded by the ARSL gene. Arylsulfatase L is a member of the arylsulfatase subfamily of sulfatase enzymes...

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sulfatase (STS), or steryl-sulfatase (EC 3.1.6.2), formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids. It is encoded...

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A lysosome (/ˈlaɪsəˌsoʊm/) is a single membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes...

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may refer to: ARSH, a type of arylsulfatase 'Arsh, a place in Taiz Governorate, Yemen Al-Arsh, or Throne of God, in Islam Arsh, a star in the constellation...

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DiGeorge syndrome, also known as 22q11.2 deletion syndrome, is a syndrome caused by a microdeletion on the long arm of chromosome 22. While the symptoms...

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progenitor cells transduced ex vivo using a lentiviral vector encoding the human arylsulfatase A gene), a gene therapy for the treatment of children...

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accessible to arylsulfatase A. Arylsulfatase A can then hydrolyze the sulfate group. Accumulation of sulfatide can cause metachromatic leukodystrophy, a lysosomal...

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Arse

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Sumatra, Indonesia River Arse, a river in the Ariège department of southern France ARSE, a former symbol for arylsulfatase L gene Animal Research – Scientific...

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009. S2CID 2346727. Tobacman JK (June 2003). "Does deficiency of arylsulfatase B have a role in cystic fibrosis?". Chest. 123 (6): 2130–2139. doi:10.1378/chest...

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Phenotypic testing of mycobacteria

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weeks (slow growers). Arylsulfatase test Arylsulfatase enzyme is present in most mycobacteria. The rate by which arylsulfatase enzyme breaks down phenolphthalein...

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ARSD

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hull classification symbol: Salvage lifting vessel (ARSD) ARSD, a type of arylsulfatase ARSD, the New York Stock Exchange symbol for the Arabian American...

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Echinocandin

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by arylsulfatase, catechol O-methyltransferase, and hydroxylation) and anidulafungin (degraded spontaneously in the system and excreted mostly as a metabolite...

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haematopoietic stem and progenitor cells transduced using a lentiviral vector encoding the human arylsulfatase A (ARSA) gene. The most common side effects include...

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BioMarin Pharmaceutical

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dihydrochloride), a small molecule drug for phenylketonuria, introduced in 2007 as the first medication-based intervention to treat phenylketonuria Arylsulfatase B (branded...

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Emil Kakkis

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recombinant human N-acetylgalactosamine 4-sulfatase (recombinant human arylsulfatase B or rhASB) and follow-on, open-label extension study. The Journal of...

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abscessus has also been shown to produce arylsulfatase, but not of nitrate reductase and Tween 80 hydrolase. It shows a negative result for the iron uptake...

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of steroid and other hormone levels by microbial glucuronidases and arylsulfatase profoundly impacted the performance of the composite entity. Following...

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ARSA or Arsa may refer to: Arylsulfatase A, gene for a human protein All-Russian Scout Association Arakan Rohingya Salvation Army, insurgent group in...

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non-chromogenic (does not produce pigment), and are positive for the 3 day arylsulfatase activity test, nitrate reductase and iron uptake. Most species are saprophytic...

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Zeng, Runying (28 November 2015). "Characterization of a Recombinant Thermostable Arylsulfatase from Deep-Sea Bacterium Flammeovirga pacifica". Journal...

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Mycobacterium botniense

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50 °C. The type strain is positive for 10-d arylsulfatase and pyrazinamidase. Negative for 3-d arylsulfatase, urease, nitrate reductase, semi-quantitative...

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triphosphate (ATP) lysosomal enzymes β-hexosaminidase β-glucuronidase arylsulfatases newly formed lipid mediators (eicosanoids): thromboxane prostaglandin...

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